CS-2802
Porcupine-IN-1
CAS: 2036044-77-4
Molecular Formula: C25H19FN4O
CS-2802 - Names and Identifiers
| Name | Porcupine-IN-1 |
| Synonyms | CS-2802 PORCN-IN-1 Porcupine-IN-1 Porcn inhibitor 1 Porcupine-IN-1 free base 9H-Carbazole-2-carboxamide, N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]- |
| CAS | 2036044-77-4 |
CS-2802 - Physico-chemical Properties
| Molecular Formula | C25H19FN4O |
| Molar Mass | 410.44 |
| Storage Condition | 2-8℃ |
| MDL | MFCD31630804 |
| In vitro study | Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor. |
| In vivo study | Porcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg). |
CS-2802 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.436 ml | 12.182 ml | 24.364 ml |
| 5 mM | 0.487 ml | 2.436 ml | 4.873 ml |
| 10 mM | 0.244 ml | 1.218 ml | 2.436 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.487 ml |
Last Update：2024-01-02 23:10:35
CS-2802 - Reference Information
| biological activity | Porcn-IN-1 are effective porcupine inhibitors with an IC50 value of 0.5±0.2 nM. |
| target | IC50: 0.5±0.2 nM (Porcupine inhibitor) |
Last Update：2024-04-09 21:04:16
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Product Name: Porcn-IN-1 Visit Supplier Webpage Request for quotationCAS: 2036044-77-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Porcn-IN-1 Visit Supplier Webpage Request for quotationCAS: 2036044-77-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: Porcupine-IN-1 Visit Supplier Webpage Request for quotationCAS: 2036044-77-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Porcupine-IN-1 Visit Supplier Webpage Request for quotationCAS: 2036044-77-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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