CS-2023
calycosin-7-o-beta-d-glucoside
CAS: 20633-67-4
Molecular Formula: C22H22O10
CS-2023 - Names and Identifiers
| Name | calycosin-7-o-beta-d-glucoside |
| Synonyms | CS-2023 CALYCOSIN 7-O-GLUCOSIDE Calycosin 7-O-Glucoside calycosin-o-glucopyranoside calycosin-7-O-β-D-glucoside Calycosin-7-O-beta-D-glucoside calycosin-7-o-beta-d-glucoside Calycosin-7-glucoside 20633-67-4 Calycosin-7-O-b-D-glucopyranoside 3',7-Dihydroxy-4'-Methoxyisoflavone-7-beta-D-glucopyranoside 3-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside 4H-1-benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)- |
| CAS | 20633-67-4 |
| InChI | InChI=1/C22H22O10/c1-29-15-5-2-10(6-14(15)24)13-9-30-16-7-11(3-4-12(16)18(13)25)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1 |
CS-2023 - Physico-chemical Properties
| Molecular Formula | C22H22O10 |
| Molar Mass | 446.41 |
| Density | 1.545 |
| Melting Point | 220 - 228°C |
| Boling Point | 745.2±60.0 °C(Predicted) |
| Flash Point | 262°C |
| Solubility | Soluble in methanol and ethanol |
| Vapor Presure | 2.51E-23mmHg at 25°C |
| Appearance | White powder |
| Color | Pale Beige |
| pKa | 9.48±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.674 |
| MDL | MFCD08061493 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol and ethanol, derived from the rhizome of Astragalus membranaceus. |
| In vitro study | Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex. |
| In vivo study | Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model. Animal Model: Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats Dosage: 26.8 mg/kg Administration: Intraperitoneal injection; 26.8 mg/kg; 14 days Result: Exhibited neuroprotective effects in rats. |
CS-2023 - Risk and Safety
| HS Code | 2932996560 |
CS-2023 - Reference Information
| Overview | Extracting and purifying from Astragalus membranaceus to prepare active ingredient calycosin-7-oxo-β-D-glucopyranoside (Calycosin-7-O-β-D-glucoside), referred to as calycosinosides, has been proved by pharmacological tests to inhibit coxsackie virus (Coxsackievirus) and treat viral myocarditis. |
| biological activity | Calycosin-7-O-β-D-glucoside is an isoflavone isolated from astragalus. It has a variety of biological activities, such as neuroprotective, cardioprotective, anti-inflammatory and antioxidant effects. |
| in vitro study | Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex. |
| in vivo study | Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model. Animal Model: Middle cerebral occlusion (MCAO) male adult Sprague-Daweley rats Dosage: 26.8 mg/kg Administration: Intraperitoneal injection; 26.8 mg/kg; 14 days Result: Exhibited neuroprotective effects in rats. |
| Animal Model: | Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats |
| Dosage: | 26.8 mg/kg |
| Administration: | Intraperitoneal injection; 26.8 mg/kg; 14 days |
| Result: | Exhibited neuroprotective effects in rats. |
| chemical properties | white crystalline powder, soluble in methanol and ethanol, derived from astragalus root. |
| uses | calycosin has antioxidant, anti-radiation and anti-cancer effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: Mainly used to improve immune function, enhance anti-oxidation, anti-radiation and anti-cancer effects, protect cardiovascular and cerebrovascular, liver, kidney and lung effects, protect brain cells, improve memory, relax vascular smooth muscle, hormone-like effects, Antibacterial and viral inhibition, lower blood lipids, lower blood sugar, reduce diabetes complications, etc. |
Last Update：2024-04-10 22:29:15
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View History
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