CS-1777
BRD73954
CAS: 1440209-96-0
Molecular Formula: C16H16N2O3
CS-1777 - Names and Identifiers
CS-1777 - Physico-chemical Properties
| Molecular Formula | C16H16N2O3 |
| Molar Mass | 284.31 |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Melting Point | 172-175oC |
| Solubility | DMSO: ≥ 35 mg/mL |
| Appearance | Solid |
| Color | Off-White |
| pKa | 8.56±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. |
CS-1777 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.517 ml | 17.586 ml | 35.173 ml |
| 5 mM | 0.703 ml | 3.517 ml | 7.035 ml |
| 10 mM | 0.352 ml | 1.759 ml | 3.517 ml |
| 5 mM | 0.07 ml | 0.352 ml | 0.703 ml |
Last Update：2024-01-02 23:10:35
CS-1777 - Reference Information
| trait | BRD73954 was white to off-white solid in appearance. |
| Use | BRD73954 is a potent small molecule inhibitor of HDAC6 and hdac8. |
| biological activity | BRD73954 is a potent and selective HDAC inhibitor, the IC50 for HDAC6 and HDAC8 were 36 nM and 120 nM, respectively. |
Last Update：2024-04-09 20:45:29
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Product Name: BRD73954 Visit Supplier Webpage Request for quotationCAS: 1440209-96-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BRD73954 Visit Supplier Webpage Request for quotationCAS: 1440209-96-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BRD73954 Visit Supplier Webpage Request for quotationCAS: 1440209-96-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
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View History
CS-1777
1,3,4-Oxadiazole, 2-[3-[(2,4-dichlorophenyl)methoxy]phenyl]-5-[[(3,4-dichlorophenyl)methyl]thio]-
2-(二苯基膦酰基)-1,4-苯二酚
4-(3-OXO-3-PHENYL-1-PROPENYL)PHENYL 3-PHENYLACRYLATE
methyl 2-{[(4-chlorophenyl)methyl]sulfanyl}acetate
Methanone, [3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1(2H)-quinolinyl]-3-pyridinyl-
3,4--二氯联苯 异辛烷溶液
Carbamic acid, N-(3-ethynyl-4-pyridinyl)-, 1,1-dimethylethyl ester
3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one, 6-acetyl- (9CI)
3-(三氟甲基)吡嗪-2(1H)-酮
1,3,4-Oxadiazole, 2-[3-[(2,4-dichlorophenyl)methoxy]phenyl]-5-[[(3,4-dichlorophenyl)methyl]thio]-
2-(二苯基膦酰基)-1,4-苯二酚
4-(3-OXO-3-PHENYL-1-PROPENYL)PHENYL 3-PHENYLACRYLATE
methyl 2-{[(4-chlorophenyl)methyl]sulfanyl}acetate
Methanone, [3,4-dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1(2H)-quinolinyl]-3-pyridinyl-
3,4--二氯联苯 异辛烷溶液
Carbamic acid, N-(3-ethynyl-4-pyridinyl)-, 1,1-dimethylethyl ester
3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one, 6-acetyl- (9CI)
3-(三氟甲基)吡嗪-2(1H)-酮