CS-1689
PU-WS13
CAS: 1454619-14-7
Molecular Formula: C17H20Cl2N6S
CS-1689 - Names and Identifiers
CS-1689 - Physico-chemical Properties
| Molecular Formula | C17H20Cl2N6S |
| Molar Mass | 411.35 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Boling Point | 617.4±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 40 mg/mL |
| pKa | 10.15±0.29(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells. |
CS-1689 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.431 ml | 12.155 ml | 24.31 ml |
| 5 mM | 0.486 ml | 2.431 ml | 4.862 ml |
| 10 mM | 0.243 ml | 1.216 ml | 2.431 ml |
| 5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
Last Update：2024-01-02 23:10:35
CS-1689 - Reference Information
| biological activity | PU-WS13 is a selective Grp94 inhibitor with an EC50 value of 0.22 μM. |
| target | GRP94 0.22 μM (EC 50 ) HSP90α 27.3 μM (EC 50 ) HSP90β 41.8 μM (EC 50 ) TRAP-1 7.3 μM (EC 50 ) |
| in vitro study | PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μ m. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μ m, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells. |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: PU-WS13 Visit Supplier Webpage Request for quotationCAS: 1454619-14-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: PU-WS13 Visit Supplier Webpage Request for quotationCAS: 1454619-14-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: PU-WS13 Visit Supplier Webpage Request for quotationCAS: 1454619-14-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: PU-WS13 Visit Supplier Webpage Request for quotation
CAS: 1454619-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1454619-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
CS-1689
2-(薄荷氧基)乙醇
氟达拉滨EP杂质D(2-氟腺苷)
BETA-D-GALACTOPYRANOSYL(1-4)-BETA-D-GLUCOPYRANOSYL CERAMIDE
DOUBLE SUGAR IRON AGAR ACC TO KLIGLER
1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 7-OXO-6-(SULFOOXY)-, 2-(4-PIPERIDINYL) ESTER, (2R,5
SER-ASN-GLU-ALA-ILE-SER-PRO-PHE-ASP-GLN-GLY-MET-MET-GLY-TYR-VAL-ILE-LYS-THR-ASN-LYS-ASN-ILE-PRO-ARG-MET-NH2
1-Naphthalenecarbonitrile, 2-[[(3-methyl-2-butenyl)oxy]methyl]-
DTBS 二(三氟甲磺酸酯)
异鲸蜡醇月桂酸酯
2-(薄荷氧基)乙醇
氟达拉滨EP杂质D(2-氟腺苷)
BETA-D-GALACTOPYRANOSYL(1-4)-BETA-D-GLUCOPYRANOSYL CERAMIDE
DOUBLE SUGAR IRON AGAR ACC TO KLIGLER
1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 7-OXO-6-(SULFOOXY)-, 2-(4-PIPERIDINYL) ESTER, (2R,5
SER-ASN-GLU-ALA-ILE-SER-PRO-PHE-ASP-GLN-GLY-MET-MET-GLY-TYR-VAL-ILE-LYS-THR-ASN-LYS-ASN-ILE-PRO-ARG-MET-NH2
1-Naphthalenecarbonitrile, 2-[[(3-methyl-2-butenyl)oxy]methyl]-
DTBS 二(三氟甲磺酸酯)
异鲸蜡醇月桂酸酯