CS-1660
(E)-2-(2-(2-(4-(trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol
CAS: 956274-94-5
Molecular Formula: C25H21F3N2O
CS-1660 - Names and Identifiers
CS-1660 - Physico-chemical Properties
| Molecular Formula | C25H21F3N2O |
| Molar Mass | 422.45 |
| Solubility | soluble in DMSO, not in water |
| Storage Condition | -20℃ |
| Use | Mavatrep is an orally bioeffective TRPV1 antagonist with high affinity for hTRPV1 channels, inhibiting the binding of TRPV1 agonists to [3H]-Resiniferatoxin (Ki = 6.5 nM), and less effective on the enzymatic activities of CYP subtypes 3A4, 1A2, and 2D6. |
CS-1660 - Reference
| Reference Show more | Parsons WH, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J Med Chem. 2015 May 14;58(9):3859-3874. |
CS-1660 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.367 ml | 11.836 ml | 23.672 ml |
| 5 mM | 0.473 ml | 2.367 ml | 4.734 ml |
| 10 mM | 0.237 ml | 1.184 ml | 2.367 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.473 ml |
Last Update：2024-01-02 23:10:35
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View History
CS-1660
1-溴-2-氟-5-甲氧基-4-硝基苯
5-甲酰基-2-噻吩甲酸甲酯
1-苯基环丁烷-1-羧酸
TNF-α(10-36) (human)
叔丁基-6-氯-4-邻甲苯基烟酰胺
乙基5-氧代吡咯烷-2-甲酸酯
3-羟基丙烷-1-磺酸钠
CY3.5
4-Azidobenzoic acid 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester
1-溴-2-氟-5-甲氧基-4-硝基苯
5-甲酰基-2-噻吩甲酸甲酯
1-苯基环丁烷-1-羧酸
TNF-α(10-36) (human)
叔丁基-6-氯-4-邻甲苯基烟酰胺
乙基5-氧代吡咯烷-2-甲酸酯
3-羟基丙烷-1-磺酸钠
CY3.5
4-Azidobenzoic acid 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester