CP466722
CP-466722
CAS: 1080622-86-1
Molecular Formula: C17H15N7O2
CP466722 - Names and Identifiers
CP466722 - Physico-chemical Properties
| Molecular Formula | C17H15N7O2 |
| Molar Mass | 349.35 |
| Density | 1.48 |
| Boling Point | 642.3±65.0 °C(Predicted) |
| Solubility | DMSO: soluble0.5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 0.00±0.19(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Use | CP-466722 is an effective, reversible ATM inhibitor that does not affect ATR and inhibits similar PI3K or PIKK in cells. |
| In vitro study | In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases. In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts. In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells. Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability. |
CP466722 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
CP466722 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.862 ml | 14.312 ml | 28.625 ml |
| 5 mM | 0.572 ml | 2.862 ml | 5.725 ml |
| 10 mM | 0.286 ml | 1.431 ml | 2.862 ml |
| 5 mM | 0.057 ml | 0.286 ml | 0.572 ml |
Last Update：2024-01-02 23:10:35
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Featured ProductsSpot supply
Product Name: CP-466722 Visit Supplier Webpage Request for quotationCAS: 1080622-86-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: CP-466722 Visit Supplier Webpage Request for quotationCAS: 1080622-86-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: CP-466722 Visit Supplier Webpage Request for quotationCAS: 1080622-86-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: CP-466722 Visit Supplier Webpage Request for quotationCAS: 1080622-86-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
CP466722
5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-
N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)nicotinamide
Methyl 1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate hydrochloride
甲基(S)-2-氨基-3-氯丙酸酯盐酸盐
3-乙基金刚烷-1-羧酸
1-(3,4-二甲氧苯基)-3-二甲基氨基-丙-2-烯-1-酮
2-乙酰基戊酸乙酯
5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-
N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)nicotinamide
Methyl 1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate hydrochloride
甲基(S)-2-氨基-3-氯丙酸酯盐酸盐
3-乙基金刚烷-1-羧酸
1-(3,4-二甲氧苯基)-3-二甲基氨基-丙-2-烯-1-酮
2-乙酰基戊酸乙酯