CML-036
6-Chloropyridazine-3-carboxylic acid
CAS: 5096-73-1
Molecular Formula: C5H3ClN2O2
CML-036 - Names and Identifiers
CML-036 - Physico-chemical Properties
| Molecular Formula | C5H3ClN2O2 |
| Molar Mass | 158.54 |
| Density | 1.579±0.06 g/cm3(Predicted) |
| Melting Point | 146 °C |
| Boling Point | 429.0±25.0 °C(Predicted) |
| Flash Point | 213.245°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White to cream |
| pKa | 2.68±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.598 |
| MDL | MFCD00160464 |
CML-036 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| HS Code | 29339980 |
| Hazard Class | IRRITANT |
CML-036 - Reference Information
| Properties | 6-chlorpyridine-3-carboxylic acid is white crystal powder at room temperature and pressure. |
| Use | 6-chlorpyridine-3-carboxylic acid can be used as a small molecule intermediate in pharmaceutical chemistry and pesticides. In the synthesis and transformation, it mainly revolves around the structure Carboxyl group, the carboxyl group can undergo esterification reaction, reduction reaction, and acyl chlorination reaction without being affected by the two nitrogen atoms in the pyridazine molecule. |
| synthesis method | add 3-chloro -6-methylpyridazine (155.6 mmol) solution in 140 mL concentrated sulfuric acid to the vacuum dry reaction bottle, and then slowly add fine powdered potassium dichromate (55.40 g) under stirring, carefully detect the reaction temperature to ensure that the temperature remains below 50°C. When the addition is completed, continue stirring at 50°C for another 4 hours. Then cool the obtained viscous dark green liquid and carefully add crushed ice, extract the reaction mixture with ethyl acetate (6 x400mL), stratify the mixture, separate the organic layer, and combine the separated ethyl acetate extract, Dry with anhydrous sodium sulfate, filter to remove the sodium sulfate solid, vacuum concentration to remove the organic solvent to obtain the target molecule 6-chlorpyridine-3-carboxylic acid, which is light red, yield 106.6 mmol 69%. Figure 6-Chlorpyridine-3-carboxylic acid synthesis route |
Last Update：2024-04-09 21:21:28
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View History
CML-036
2-(4-硝基苯基)恶唑-4-羧酸
4-氟-3-甲酰基苯硼酸 (含有数量不等的酸酐)
3-氨基苯甲酸乙酯甲基磺酸盐
5-FORMYLPYRIDIN-2-YL-2-BORONIC ACID
5-甲砜基-6-硝基苯骈恶唑酮
4-硝基苯基-Β-D-吡喃岩藻糖苷
1-alpha-h,5-alpha-h-tropan-3-alpha-ol,mandelate(ester)
庚基碳酰氯
Boronic acid, [3-(2-propoxyethoxy)phenyl]- (9CI)
2-(4-硝基苯基)恶唑-4-羧酸
4-氟-3-甲酰基苯硼酸 (含有数量不等的酸酐)
3-氨基苯甲酸乙酯甲基磺酸盐
5-FORMYLPYRIDIN-2-YL-2-BORONIC ACID
5-甲砜基-6-硝基苯骈恶唑酮
4-硝基苯基-Β-D-吡喃岩藻糖苷
1-alpha-h,5-alpha-h-tropan-3-alpha-ol,mandelate(ester)
庚基碳酰氯
Boronic acid, [3-(2-propoxyethoxy)phenyl]- (9CI)