CLIP
CLIP
CAS: 53917-42-3
Molecular Formula: C112H165N27O36
CLIP - Names and Identifiers
CLIP - Physico-chemical Properties
| Molecular Formula | C112H165N27O36 |
| Molar Mass | 2465.67 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| Storage Condition | -20°C |
| In vitro study | The ACTH family of polypeptides consists of ACTH(1-39) (adrenocorticotropin), ACTH (1-13)amide (α-melanotropin;α-MSH); and ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia. |
CLIP - Risk and Safety
| WGK Germany | 3 |
CLIP - Reference Information
| biological activity | Adrenocorticotropic Hormone (ACTH) (18-39), human is a kind of corticotropin-like mid-lobe peptide produced in melanocytes in the middle lobe of pituitary gland. |
| in vitro study | The ACTH family of polypeptides consists of ACTH (1-39) (adrenocorticotropin), ACTH (1-13) amide (α-melanotropin;α-MSH); And ACTH (18-39) (corticotropinlike intermediate lobe peptide, CLIP). These polypeptides are derived from a common precursor, proopiomelanocortin. In corticotropic cells of the pars distalis, proopiomelanocortin (POMC) undergoes a series of proteolytic cleavage reactions to yield ACTH (1-39) as a major end product. However, in the melanotropic cells of the pars intermedia, an additional set of proteolytic reactions results in the conversion of ACTH (1-39) to ACTH (1-13) amide and ACTH (18-39). In several species of vertebrates, ACTH (1-13) amide undergoes end product modification to yield mono- and diacetylated forms ofα-MSH as major end products in the pars intermedia. |
Last Update：2024-04-09 21:49:45
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View History
CLIP
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3,6-二氯-2-氟苯甲醛
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硫柠胆蔗琼脂(TCBS)
2-氯-8-甲氧基喹唑啉-4-酮
4-氨基-5-胺碳酰盐酸盐
2-(4-氯苯基)-1-苯基萘
8-Azabicyclo[3.2.1]octan-3-one hydrochloride
3-(环氧乙烷-2-基甲氧基)苯并[D]异噁唑
2-(4-硝基苯基)-1,3-二硝基丙烷
3,6-二氯-2-氟苯甲醛
2-(4-甲氧基苯基)环氧乙烷
硫柠胆蔗琼脂(TCBS)
2-氯-8-甲氧基喹唑啉-4-酮