CCG 203971
CCG-203971
CAS: 1443437-74-8
Molecular Formula: C23H21ClN2O3
CCG 203971 - Names and Identifiers
CCG 203971 - Physico-chemical Properties
| Molecular Formula | C23H21ClN2O3 |
| Molar Mass | 408.88 |
| Density | 1.305±0.06 g/cm3(Predicted) |
| Boling Point | 656.0±55.0 °C(Predicted) |
| Appearance | powder |
| Color | white to beige |
| pKa | 13.69±0.70(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | CCG-203971, a second-generation Ras homolog gene family, member A (RhoA)/myocardin-related transcription factor A (MRTF-A)/serum response factor (SRF) pathway inhibitor, represses both matrix-stiffness and transforming growth factor beta–mediated fibrogenesis as determined by protein and gene expression in a dose-dependent manner. CCG-203971 significantly represses TGF-β- induced MKL1 expression at 25 μM concentration. Human dermal fibroblasts are plated onto 96-well plates and allowed to grow for 3 days in the presence of 30 μM CCG-203971 or DMSO vehicle. Viable cell density is assessed through enzymatic reduction of the water-soluble tetrazolium dye WST-1. Scleroderma dermal fibroblasts proliferate faster than normal cells, and this is inhibited by CCG-203971. |
| In vivo study | CCG-203971 is tested in a Bleomycin skin injury model. Bleomycin is administered in 50 μL of DMSO intraperitoneally. Preliminary studies show that Bleomycin administered in this manner is well tolerated at 100 mg/kg twice a day. Intradermal Bleomycin for 2 weeks along with the DMSO control (50 μL i.p.) results in marked dermal thickening (P<0.0001) compared with the PBS+DMSO group, which does not receive Bleomycin. CCG-203971 treatment strongly and significantly (P<0.001) suppresses the Bleomycin-induced skin thickening in this model. Skin collagen amounts, assessed by measurement of hydroxyproline content, show similar results. Bleomycin injections promote collagen deposition (P<0.01) and CCG-203971 is able to block this effect (P<0.05). |
CCG 203971 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.446 ml | 12.229 ml | 24.457 ml |
| 5 mM | 0.489 ml | 2.446 ml | 4.891 ml |
| 10 mM | 0.245 ml | 1.223 ml | 2.446 ml |
| 5 mM | 0.049 ml | 0.245 ml | 0.489 ml |
Last Update：2024-01-02 23:10:35
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Tel: +86-400-900-4166
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Mobile: +86-18621343501
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View History
CCG 203971
N-butyl-2-{[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}propanamide
3-Hydroxyhippuricacid
HAMAMELISWATER
butan-2-yl[(2,4-dichlorophenyl)methyl]amine
AKOS B000717
N-FMOC-3-环己基-L-丙氨酸
(R)-tert-butyl 2-aMino-2-phenylethylcarbaMate
105362-06-9
Tiotropium Bromide BP Impurity H
N-butyl-2-{[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}propanamide
3-Hydroxyhippuricacid
HAMAMELISWATER
butan-2-yl[(2,4-dichlorophenyl)methyl]amine
AKOS B000717
N-FMOC-3-环己基-L-丙氨酸
(R)-tert-butyl 2-aMino-2-phenylethylcarbaMate
105362-06-9
Tiotropium Bromide BP Impurity H