CCG-203971_化工百科

中文名	CCG-203971
英文名	CCG-203971
别名	化合物CCG203971 N-(4-氯苯基)-1-(3-(2-呋喃基)苯甲酰基)-3-哌啶甲酰胺
英文别名	203971 CCG203971 CCG-203971 CCG 203971 N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide 3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-
CAS	1443437-74-8
化学式	C23H21ClN2O3
分子量	408.88
密度	1.305±0.06 g/cm3(Predicted)
沸点	656.0±55.0 °C(Predicted)
酸度系数	13.69±0.70(Predicted)
存储条件	2-8°C
外观	粉末
颜色	white to beige
体外研究	CCG-203971, a second-generation Ras homolog gene family, member A (RhoA)/myocardin-related transcription factor A (MRTF-A)/serum response factor (SRF) pathway inhibitor, represses both matrix-stiffness and transforming growth factor beta–mediated fibrogenesis as determined by protein and gene expression in a dose-dependent manner. CCG-203971 significantly represses TGF-β- induced MKL1 expression at 25 μM concentration. Human dermal fibroblasts are plated onto 96-well plates and allowed to grow for 3 days in the presence of 30 μM CCG-203971 or DMSO vehicle. Viable cell density is assessed through enzymatic reduction of the water-soluble tetrazolium dye WST-1. Scleroderma dermal fibroblasts proliferate faster than normal cells, and this is inhibited by CCG-203971.
体内研究	CCG-203971 is tested in a Bleomycin skin injury model. Bleomycin is administered in 50 μL of DMSO intraperitoneally. Preliminary studies show that Bleomycin administered in this manner is well tolerated at 100 mg/kg twice a day. Intradermal Bleomycin for 2 weeks along with the DMSO control (50 μL i.p.) results in marked dermal thickening (P<0.0001) compared with the PBS+DMSO group, which does not receive Bleomycin. CCG-203971 treatment strongly and significantly (P<0.001) suppresses the Bleomycin-induced skin thickening in this model. Skin collagen amounts, assessed by measurement of hydroxyproline content, show similar results. Bleomycin injections promote collagen deposition (P<0.01) and CCG-203971 is able to block this effect (P<0.05).

CCG-203971 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.446 ml	12.229 ml	24.457 ml
5 mM	0.489 ml	2.446 ml	4.891 ml
10 mM	0.245 ml	1.223 ml	2.446 ml
5 mM	0.049 ml	0.245 ml	0.489 ml

最后更新：2024-01-02 23:10:35

上海麦克林生化科技股份有限公司

主打产品现货供应

产品名: CCG-203971 去供应商网站查看询盘
CAS: 1443437-74-8
产地: 上海
规格: C872817
价格: 5mg-211,25mg-603,100mg-1475,1ml-490
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266

微信: 19863730987/17821173903

MedChemExpress

现货供应

产品名: CCG-203971 去供应商网站查看询盘
CAS: 1443437-74-8
产地: 美国
包装: 10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-108361
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
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产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98.0%

北京索莱宝科技有限公司

现货供应

产品名: N-(4-氯苯基)-1-(3-(2-呋喃基)苯甲酰基)-3-哌啶甲酰胺去供应商网站查看询盘
CAS: 1443437-74-8
产地: 北京
包装: 瓶
规格: YS143642-10mg,YS143642-50mg,YS143642-100mg,YS143642-25mg,YS143642-1g,YS143642-250mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
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QQ: 3193328036

微信: 17801761073
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术更多

上海吉至生化科技有限公司

现货供应

产品名: CCG-203971 去供应商网站查看询盘
CAS: 1443437-74-8
产地: 中国上海
包装: 25mg，10mg，100mg，50mg
价格: 面议、电联、微信、QQ
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名称：CCG-203971 ，英文名称：CCG-203971，CAS：1443437-74-8 ，包装：25mg，10mg，100mg，50mg ，价格：面更多

上海源叶生物科技有限公司

现货供应

产品名: CCG-203971 去供应商网站查看询盘
CAS: 1443437-74-8
产地: 上海
规格: 98%
价格: 5mg 192,10mg 360,25mg 784,50mg 1440,100mg 2560
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
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