CALCIUM IONOPHORE A23187 HEMICALCIUM SALT

Name	Calcimycin hemicalcium salt
Synonyms	A23187 HEMICALCIUM SALT A-23187 hemicalcium salt Calcimycin hemicalcium salt CALCIMYCIN A23187 HEMICALCIUM SALT calcium ionophore A23187 hemicalcium CALCIUM IONOPHORE A23187 HEMICALCIUM SALT CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
CAS	59450-89-4

Molecular Formula	C58H72CaN6O12
Molar Mass	1085.32
Solubility	DMSO: soluble
Appearance	powder
Color	yellow
BRN	6765084
Storage Condition	2-8°C
In vitro study	Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	-
FLUKA BRAND F CODES	8

biological activity	calcycin hemicalium salt (A-23187 hemicalium salt) it is an antibiotic and a unique divalent cation ionophore, such as calcium and magnesium ions. Calcycin hemicalum salt induces Ca2 dependent cell death by increasing intracellular calcium concentration. Calcycin hemicalum salt inhibits the growth of gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and decouples oxidative phosphorylation of mammalian cells, inducing apoptosis.
Animal Model:	Mice (ICR, 25-30 g)
Dosage:	2.5 or 7.5 nM
Administration:	Intrapleurally
Result:	Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Use	the highly selective calcium ionophore enhances the response to NMDA non-nitrosamine. In cell culture, the production of nitric oxide is stimulated by calmodulin-dependent constitutive nitric oxide synthase.

Last Update：2024-04-09 21:11:58

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