Calcimycin hemicalcium salt MedChemExpress (MCE)

Product Name	Calcimycin hemicalcium salt
Synonyms	A23187 HEMICALCIUM SALT A-23187 hemicalcium salt Calcimycin hemicalcium salt CALCIMYCIN A23187 HEMICALCIUM SALT calcium ionophore A23187 hemicalcium CALCIUM IONOPHORE A23187 HEMICALCIUM SALT Synonyms A23187 HEMICALCIUM SALT A-23187 hemicalcium salt Calcimycin hemicalcium salt CALCIMYCIN A23187 HEMICALCIUM SALT calcium ionophore A23187 hemicalcium CALCIUM IONOPHORE A23187 HEMICALCIUM SALT CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
CAS	59450-89-4
EINECS
Chemical Formula	C58H72CaN6O12
Molecular Weight	1085.32
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Calcimycin hemicalcium salt Calcimycin hemicalcium salt MedChemExpress (MCE) HY-N6687A 59450-89-4 A-23187 hemicalcium salt Descriptions Calcimycin hemicalcium salt Calcimycin hemicalcium salt MedChemExpress (MCE) HY-N6687A 59450-89-4 A-23187 hemicalcium salt Antibiotic A-23187 hemicalcium salt Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis. Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4]. Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM intrapleurally) induces protein leakage[5]. \| \| \| \| \| \| \| \| \| \| [1]. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar 55(3):974-82. [Content Brief] [2]. Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb 4(2):189-94. [Content Brief] [3]. Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct 9(10):1475-90. [Content Brief] [4]. Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec 1861(12):3190-3200. [Content Brief] [5]. Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul 350(1):90-5. [Content Brief]
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Last Update	2025-05-21 16:50:25

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