CALCITONIN GENE RELATED PEPTIDE (8-37) RAT
ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-
CAS: 129121-73-9
Molecular Formula: C138H224N42O41
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT - Names and Identifiers
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT - Physico-chemical Properties
| Molecular Formula | C138H224N42O41 |
| Molar Mass | 3127.51 |
| Storage Condition | -20°C |
| In vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| In vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels. |
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.32 ml | 1.599 ml | 3.197 ml |
| 5 mM | 0.064 ml | 0.32 ml | 0.639 ml |
| 10 mM | 0.032 ml | 0.16 ml | 0.32 ml |
| 5 mM | 0.006 ml | 0.032 ml | 0.064 ml |
Last Update：2024-01-02 23:10:35
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT - Reference Information
| biological activity | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selected CGRP receptor antagonist. |
| target | CGRP receptor |
| in vitro study | CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor. |
| in vivo study | CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a pose-dependent manner. The 50 nM pose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basic levels. |
Last Update：2024-04-09 21:54:55
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View History
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT
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3-chlorobenzenecarboximidamide hydrochloride (1:1)
ALFUZOSIN HYDROCLORIDE
多扎格列艾汀杂质43
(4-((2-氟苯基)氨基甲酰基)苯基)硼酸
环HEPT-1-烯-1-基BORONICACID
Valeric acid 1-methylethyl ester
TOSLAB 824280
2-({[(9H-芴-9-基)甲氧基]羰基}(2-甲基丙基)氨基)乙酸
4-Formylcyclohexanone
3-chlorobenzenecarboximidamide hydrochloride (1:1)
ALFUZOSIN HYDROCLORIDE
多扎格列艾汀杂质43
(4-((2-氟苯基)氨基甲酰基)苯基)硼酸
环HEPT-1-烯-1-基BORONICACID
Valeric acid 1-methylethyl ester
TOSLAB 824280
2-({[(9H-芴-9-基)甲氧基]羰基}(2-甲基丙基)氨基)乙酸