Boc-Val-Cit-PABC-PNP
Boc-Val-Cit-PAB-PNP
CAS: 870487-10-8
Molecular Formula: C30H40N6O10
Boc-Val-Cit-PABC-PNP - Names and Identifiers
Boc-Val-Cit-PABC-PNP - Physico-chemical Properties
| Molecular Formula | C30H40N6O10 |
| Molar Mass | 644.67 |
| Density | 1.291±0.06 g/cm3(Predicted) |
| Boling Point | 896.0±65.0 °C(Predicted) |
| Solubility | ( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| pKa | 11.25±0.46(Predicted) |
| Storage Condition | -20℃ |
| Use | Boc-Val-Cit-PAB-PNP is a degradable (cleavable) ADC linker that can be used to synthesize antibody-coupled drugs (ADC). |
| Target | Cleavable |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| In vivo study | The ADC is composed of an antibody, and the ADC cytotoxin is bound to the antibody via the ADC linker. |
Boc-Val-Cit-PABC-PNP - Reference
| Reference Show more | 1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
Boc-Val-Cit-PABC-PNP - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.551 ml | 7.756 ml | 15.512 ml |
| 5 mM | 0.31 ml | 1.551 ml | 3.102 ml |
| 10 mM | 0.155 ml | 0.776 ml | 1.551 ml |
| 5 mM | 0.031 ml | 0.155 ml | 0.31 ml |
Last Update：2024-01-02 23:10:35
Boc-Val-Cit-PABC-PNP - Reference Information
| use | Boc-Val-Cit-PAB-PNP is a cleavable (cleavable) ADC linker that can be used to synthesize antibody-coupled drugs (ADC). |
| in vivo study | ADC consists of antibodies, which bind ADC cytotoxins to antibodies through ADC connectors. |
| biological activity | Boc-Val-Cit-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-coupled drugs (ADCs). |
| target | Cleavable |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Last Update：2024-04-09 21:21:28
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View History
Boc-Val-Cit-PABC-PNP
(E)-3-[4-methoxy-3-[(4-methyl-1-pyrazolyl)methyl]phenyl]prop-2-enoic acid
2-甲氧基-5-乙砜基苯甲酸甲酯
(E)-3-[4-methoxy-3-[(4-methyl-1-pyrazolyl)methyl]phenyl]prop-2-enoic acid
2-甲氧基-5-乙砜基苯甲酸甲酯