Boc-N-methyl-DL-phenylalanine - Names and Identifiers
Boc-N-methyl-DL-phenylalanine - Physico-chemical Properties
Boc-N-methyl-DL-phenylalanine - Introduction
Phenylalanine, N-[(1,1-dimenthylethoxy) carbonyl]-N-methyl-, chemical name Phenylalanine-, N-[(1,1-dimenthylethoxy) carbonyl]-N-methyl-, is an unnatural amino acid derivative. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Chemical formula: C16H21NO4
2. molecular weight: 291.34g/mol
3. Appearance: white crystal or crystalline powder
4. Melting point: about 185°C
5. Solubility: insoluble in water, slightly soluble in ethanol and dimethyl sulfoxide
Use:
Phenylalanine, N-[(1,1-dimenthylethoxy) carbonyl]-N-methyl-has a wide range of applications in the field of organic synthesis:
1. as a synthetic intermediate of pharmaceutical compounds, used in the synthesis of drugs, anti-tumor compounds and antiviral compounds.
2. for the synthesis of peptides, proteins and other related compounds in biochemical research.
Preparation Method:
Phenylalanine, the preparation of N-[(1,1-dimenthylethoxy) carbonyl]-N-methyl-can be carried out by the following steps:
1. Reaction of DL-phenylalanine with 1,1-dimethyl-2-aminoethanol (DMEAE) under alkaline conditions to give N-(1,1-dimethylethoxycarbonyl)-N-methyl-DL-phenylalanine.
2. N-(1,1-Dimethylethoxycarbonyl)-N-methyl-DL-phenylalanine is then reacted with triflate (TFMS) or butyryl succinate (Boc2O) to give Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-.
Safety Information:
Phenylalanine, the safe operation of N-[(1,1-dimenthylethoxy) carbonyl]-N-methyl-should follow laboratory practices and personal protective measures. It has no obvious toxicity to human body under normal conditions, but it should be handled with caution and avoid inhalation, intake or contact with skin and eyes. During use, attention should be paid to avoid dust and ensure good ventilation. Appropriate personal protective equipment, such as goggles, gloves and lab clothes, should be provided if necessary. In case of contact, rinse immediately with plenty of water and seek medical help.
Last Update:2024-04-09 15:17:59