Molecular Formula | C14H16O9 |
Molar Mass | 328.27 |
Density | 1.3901 (rough estimate) |
Melting Point | 237-240°C(lit.) |
Boling Point | 386.03°C (rough estimate) |
Specific Rotation(α) | D18 -37.7° (c = 1.96 in ethanol); D24 -45.3° (c = 0.51 for anhydr in water) |
Flash Point | 250.6°C |
Solubility | Dissolve in methanol, slightly soluble in water or ethanol. |
Vapor Presure | 2.92E-18mmHg at 25°C |
Appearance | White loose needle crystal or crystalline powder |
Color | White to Off-White |
Maximum wavelength(λmax) | ['277nm(EtOH)(lit.)'] |
pKa | 8.26±0.70(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.6550 (estimate) |
MDL | MFCD00167248 |
Physical and Chemical Properties | White loose needle-like crystals or crystalline powder. Melting point 238 °c. Soluble in water, soluble in alcohol. Odorless, bitter, and gradually discolored when exposed to light and heat. |
Use | Antitussive and expectorant for prevention and treatment of chronic bronchitis |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | UQ0337200 |
HS Code | 29329990 |
Reference Show more | 1. Ma Ji-ping, Liu Danhua, Hao Haijun, et al. Preparation and pharmacokinetics of Phloretin-phospholipid complex [J]. Chinese traditional medicines, 2020, v.42(06):183-186. 2. Zhang Ya, Wang Yiqiao, Ma Zhuoya, et al. Optimization of water extraction and alcohol precipitation process of zhuangyao Baijin granules by pharmacodynamic experiment combined with orthogonal test [J]. China Pharmacy, 2020, v.31;No.674(08):28-34. 3. [IF = 5.64] Wu Dousheng et al."Oleanolic acids the Type III secret System of Ralstonia solanacearum." Front Microbiol. 2015 Dec;0:1466 |
is a white loose needle-like crystal or crystalline powder, melting point 238 ℃, soluble in water, soluble in ethanol. Odorless, bitter, and gradually discolored when exposed to light and heat.
with the crude drug saximaraceae plant Chinese cabbage as raw material extraction.
for antitussive expectorant, for the treatment of chronic bronchitis.
pharmacological effects | bergenin, also known as dwarf tea element, is Bergenia purpurscens(Hook.f.et Thoms.)Engl. A needle-like or crystalline powder extracted from the whole plant. Rock cabbage is a new variety in the 2015 edition of the Pharmacopoeia. Rock cabbage is mainly produced in Sichuan, Yunnan, Tibet and other places. Harvest in spring and autumn, wash away the sediment, remove the decayed leaves of the root, and dry in the sun. (1) Bergenin intraperitoneal injection and gavage have obvious antitussive effect on mice and cats. According to animal experiments, the antitussive mechanism of bergenin is to inhibit the central center, but it is different from morphine central antitussive drugs. It is characterized by selectively inhibiting the cough center, but has no obvious enhancement and inhibitory effect on other centers. (2) bergenin has a good broad-spectrum antibacterial effect, can inhibit Shigella, Staphylococcus aureus and Pseudomonas aeruginosa, and has antiviral effect; bergenin has the effect of promoting the recovery of diseased tissues. |
source plant | rock cabbage is also known as dull cabbage, rock wall vegetable, red rock 7. rock seven. It was first published in "A Study of Plant Name". Bergeniapurpurascens (Hook. f. et Thoms.)Engl. Or thick-leaved rock cabbage B. crassifolia (L.) Fritsch rhizome or whole grass. The former is distributed in Yunnan, Sichuan, Tibet and other provinces; the latter is distributed in the Altai Mountains of Xinjiang. Used medicinal materials for the Naxi people. This product is bitter, astringent and flat in nature. Function expectorant and antitussive, astringent and hemostatic, antidiarrheal. Indications of cough, hematemesis, hemoptysis, hematochezia, functional uterine bleeding, traumatic bleeding, diarrhea, dysentery, turbidity, red leucorrhea and other syndromes. If this product is decocted with Ajuga vulgaris, or rock cabbage slices can be used to treat chronic bronchitis; with Baibu, lily, asparagus, Ophiopogon japonicus, etc., it can be used to treat tuberculosis and cough. In addition, this product is also used for rheumatic pain, bruises, and has the effect of relaxing muscles and activating collaterals. It is also used as a tonic and strong medicine to treat physical deficiency and dizziness. You can still use topical tamping to treat yellow water sores. Fried clothes, 6~12g. Experimental study: The whole grass of Chinese cabbage contains bergenin and other coumarins. The rhizome contains bergenin. The root of thick-leafed rock cabbage contains arbutol glycosides. Tannin. Chinese cabbage has antitussive effect on mice. the antitussive effect of 300 mg/kg is similar to codeine phosphate 60 mg/kg. Bergenin also has antitussive effect. It can be used to treat chronic tracheitis. The immersion agent has an inhibitory effect on Shigella in the test tube, and can treat dysentery and diarrhea. thick leaf rock cabbage is rich in vitamin P, its water extract to rats long-term oral, can increase capillary resistance, no toxic reaction. Figure 1 shows rock cabbage. |
efficacy | bergenin is an effective ingredient of Chinese cabbage, which has antitussive and expectorant effects. it is a "special effect" drug for treating chronic bronchitis, emphysema, bronchial asthma and other respiratory diseases. A variety of compound preparations using bergenin as raw material have been used for clinical treatment of chronic bronchitis, chronic bronchitis, etc. For example, compound bergenin tablets developed by Yunnan Baiyao Group and Bailing compound bergenin tablets developed by Guizhou Bailing Pharmaceutical are all Chinese patent medicines for the treatment of chronic bronchitis. In addition, bergenin also has the function of scavenging free radicals and inhibiting lipid peroxidation, and has no toxic side effects. This effect is just in line with the popular skin care concepts such as anti-oxidation and free radical scavenging proposed by the cosmetics industry in recent years. Therefore, many cosmetics manufacturers have added rock cabbage as an antioxidant raw material to skin care products. |
principle of action | bergenin has analgesic, sedative, hypnotic and stabilizing effects. There is no respiratory inhibition at the therapeutic dose, and it does not cause gastrointestinal smooth muscle spasm. It has a good effect on chronic persistent pain and internal organ blunt pain, and a poor effect on acute acute pain (such as postoperative pain, traumatic pain, etc.) and advanced cancer pain. While producing analgesic effect, it can cause sedation and hypnosis. |
apply | for chronic bronchitis. The original medicinal material "Rock Cabbage" of this product is sweet, astringent and cool in nature. Function to relieve lung cough, stop bleeding and relieve diarrhea, promote blood circulation and dredge collaterals, strong, used for tuberculosis cough, hemoptysis, hematochezia, diarrhea, rheumatic arthralgia, bruises, etc. |
use | antitussive and expectorant. For the treatment of chronic bronchitis. antitussive and expectorant, for the prevention and treatment of chronic bronchitis by inhibiting the formation of interleukin 1beta and tumor necrosis factor alpha. |
production method | crude medicine (asilam or asilis) coarse powder is taken, soaked and boiled with 95% ethanol, the obtained ethanol solution is concentrated to recover ethanol, and concentrated ammonia water is added to the pH9-10 solution to precipitate and precipitate the crude bergenin. The crude product is dissolved in ethanol, decolorized with activated carbon, and recrystallized to obtain the finished product of bergenin, and the yield is 1.5% based on crude drugs. |