Benthiozone
Thioacetazone
CAS: 104-06-3
Molecular Formula: C10H12N4OS
Benthiozone - Names and Identifiers
Benthiozone - Physico-chemical Properties
| Molecular Formula | C10H12N4OS |
| Molar Mass | 236.29 |
| Density | 1.2752 (rough estimate) |
| Melting Point | 225-230 °C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| pKa | 11.35±0.70(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.6440 (estimate) |
| Physical and Chemical Properties | Light yellow crystal or crystalline powder. Decomposition at 225-230 °c. Soluble in hot alcohol, slightly soluble in cold alcohol, very slightly soluble in water, insoluble in chloroform, ether, soluble in potassium hydroxide ethanol solution. |
| In vitro study | Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl. |
| In vivo study | The K m and V max values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat. |
Benthiozone - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | AE3850000 |
| HS Code | 29309090 |
| Toxicity | LD50 s.c. in mice: 1-2 g/kg (Bavin) |
Benthiozone - Reference Information
| biological activity | Thiacetazone (Thioacetazone) is an antituberculous agent containing thiourea and an orally active antibiotic. Thiacetazone has antibacterial effect and can inhibit the growth of Mycobacterium tuberculosis H37Rv (Mycobacterium tuberculosis H37Rv) with MIC value of 0.1 μg/mL. |
| target | MIC: 0.1 μg/mL ( Mycobacterium tuberculosis H37Rv ) |
| use | this product can inhibit tuberculosis and leprosy, and change the morphology, particle disappearance and chromatin of the bacteria. It was first used to treat leprosy, and its effect is not as good as sulfones, but it has a good effect on tuberculosis leprosy. |
| Production method | It is obtained by the reaction of p-acetaminobenzaldehyde and hydrazine thiocyanate in glacial acetic acid at 104 ℃. The yield of this method is 95%. |
Last Update：2024-04-09 20:13:35
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CAS: 104-06-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Multiple SpecificationsSpot supply
Product Name: Thioacetazone; Amithiozone Visit Supplier Webpage Request for quotationCAS: 104-06-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: THIACETAZONE Visit Supplier Webpage Request for quotationCAS: 104-06-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Thiacetazone Visit Supplier Webpage Request for quotationCAS: 104-06-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Thiacetazone Visit Supplier Webpage Request for quotation
CAS: 104-06-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 104-06-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Benthiozone
206069-14-9
1H-Benzimidazole, 2-(4-methoxyphenyl)-1-(2-propyn-1-yl)-
4-(TRANS-4-HYDROXYCYCLOHEXYLCARBAMOYL)PHENYLBORONIC ACID
IridiuM, tris[2-(6-Methyl-5-phenyl-2-pyridinyl-kN)phenyl-kC]
Ethanol,2-[2-[1-(4-methoxyphenoxy)ethoxy]ethoxy]-, 1-acetate
N-(1-METHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)ACETAMIDE
AMINO-(2-FLUORO-PHENYL)-ACETIC ACID
E 6801
8,13-BIS(SULFONIC ACID)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID DIHYDROCHLORIDE
206069-14-9
1H-Benzimidazole, 2-(4-methoxyphenyl)-1-(2-propyn-1-yl)-
4-(TRANS-4-HYDROXYCYCLOHEXYLCARBAMOYL)PHENYLBORONIC ACID
IridiuM, tris[2-(6-Methyl-5-phenyl-2-pyridinyl-kN)phenyl-kC]
Ethanol,2-[2-[1-(4-methoxyphenoxy)ethoxy]ethoxy]-, 1-acetate
N-(1-METHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-4-YL)ACETAMIDE
AMINO-(2-FLUORO-PHENYL)-ACETIC ACID
E 6801
8,13-BIS(SULFONIC ACID)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID DIHYDROCHLORIDE