BMS-5
N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
CAS: 1338247-35-0
Molecular Formula: C17H14Cl2F2N4OS
BMS-5 - Names and Identifiers
BMS-5 - Physico-chemical Properties
| Molecular Formula | C17H14Cl2F2N4OS |
| Molar Mass | 431.29 |
| Density | 1.54±0.1 g/cm3(Predicted) |
| Solubility | DMSO :34 mg/mL (78.83 mM) |
| Appearance | White powder. |
| pKa | 9.51±0.50(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in Nf2 ΔEx2 mouse Schwann cells (MSCs) with an IC 50 of ~2 µM. BMS-5 (LIMKi 3) reduces Nf2 ΔEx2 MSC viability in a dose-dependent manner with an IC 50 of 3.9 µM, but does not significantly reduce the viability of control Nf2 flox2/flox2 MSCs at equivalent BMS-5 concentrations. At 10 µM BMS-5, Nf2 ΔEx2 MSC viability is 40% compared to 83% for controls. |
| In vivo study | BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01). |
BMS-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.319 ml | 11.593 ml | 23.186 ml |
| 5 mM | 0.464 ml | 2.319 ml | 4.637 ml |
| 10 mM | 0.232 ml | 1.159 ml | 2.319 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.464 ml |
Last Update：2024-01-02 23:10:35
BMS-5 - Reference Information
| biological activity | BMS-5 (LIMKi 3) is a potent inhibitor of LIM kinases (LIMK), the IC50 values for LIMK1 and LIMK2 were 7 nM and 8 nM, respectively. |
| Target | Value |
| LIMK1 (Cell-free assay) | 7 nM |
| LIMK2 (Cell-free assay) | 8 nM |
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: LIMKi 3 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BMS-5 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BMS-5 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: LIMKi 3 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BMS-5 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BMS-5 Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide Visit Supplier Webpage Request for quotationCAS: 1338247-35-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
BMS-5
2-Chloro-3-fluoroisonicotinaldehyde hydrate (1:1)
Compstatin analog peptide CP40
6-CHLOROPYRIDINE-3-CARBONYL CHLORIDE
O,O-Dimethylphosphorodithioic acid ammonium salt
Loratadine Impurity 72
3-Penten-2-one, (3E)-
3,6,9-Trioxadecanoic acid (TODS)
ene)Bis(2-MethyL
3-Azabicyclo[3.1.0]hexane-6-carboxylic acid, 2,4-dioxo-3-[3-(trifluoromethyl)phenyl]-, ethyl ester
2-Chloro-3-fluoroisonicotinaldehyde hydrate (1:1)
Compstatin analog peptide CP40
6-CHLOROPYRIDINE-3-CARBONYL CHLORIDE
O,O-Dimethylphosphorodithioic acid ammonium salt
Loratadine Impurity 72
3-Penten-2-one, (3E)-
3,6,9-Trioxadecanoic acid (TODS)
ene)Bis(2-MethyL
3-Azabicyclo[3.1.0]hexane-6-carboxylic acid, 2,4-dioxo-3-[3-(trifluoromethyl)phenyl]-, ethyl ester