Molecular Formula | C13H25N3O5 |
Molar Mass | 303.3547 |
Storage Condition | 2~8℃,干燥,密封 |
In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
biological activity | N3-PEG3-CH2CH2-Boc is a degradable (cleavable) ADC linker containing 3 unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). N3-PEG3-CH2CH2-Boc is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules. |
target | PEGs Alkyl/ether Cleavable |
in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |