Molecular Formula | C22H24ClN3O |
Molar Mass | 381.9 |
Density | 1.1505 (rough estimate) |
Melting Point | 111 - 115°C |
Boling Point | 533.9±60.0 °C(Predicted) |
Solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | pKa 9.82(H2O t=25 I=0.025) (Uncertain) |
Storage Condition | 2-8°C |
Refractive Index | 1.5790 (estimate) |
Physical and Chemical Properties | Oils. Soluble in dichloromethane. Monohydrate: Crystallized from ethanol-water. Two different crystal forms can be identified. Azogastine hydrochloride (Azelastine Hydrochloride):C22H24ClN3O?HCl. [79307-93-0]. White crystalline powder, odorless, bitter taste. Soluble in chloroform, dichloromethane or glacial acetic acid, slightly soluble in methanol, slightly soluble in absolute ethanol or water, insoluble in acetone or ether. Melting point 225~229 ℃. Acute toxicity LD50 male and female mice, male and female rats, male and female guinea pigs (mg/kg):124,139,310,417,126,130 orally; 36.5,35.5,26.9,30.3,23.0,24.8 intravenous injection; 597.0,57.2,143.0,115.0,46.2,52.2 intramuscular injection; 63.0,54.2,66.5,59.6. 41.0.37.3 Subcutaneous injection. |
Toxicity | LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81 |
Reference Show more | 1. Li, Meng, et al. "Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS." New Journal of Chemistry 44.15 (2020): 5819-5827.https://doi.org/10.1039/D0NJ00095G |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.618 ml | 13.092 ml | 26.185 ml |
5 mM | 0.524 ml | 2.618 ml | 5.237 ml |
10 mM | 0.262 ml | 1.309 ml | 2.618 ml |
5 mM | 0.052 ml | 0.262 ml | 0.524 ml |