Molecular Formula | C11H15N5O3 |
Molar Mass | 265.27 |
Melting Point | 213~215℃ |
Storage Condition | 2-8°C |
In vitro study | The IC 50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC 50 value of Aristeromycin at 50 μM SAH is 12.7 nM. Aristeromycin has IC 50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth. At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a. |
WGK Germany | 3 |
RTECS | GY4250000 |
biological activity | aristeromyin, adenosine analogs, is an antibiotic and potent S-adenosyl homocysteine hydrolase (AHCY) inhibitor. |
Target | S-adenosylhomocysteine hydroase |