Name | Aminooxy-PEG4-alcohol |
Synonyms | Aminooxy-PEG4-alcohol 2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethanol Ethanol, 2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]- |
CAS | 106492-60-8 |
Molecular Formula | C8H19NO5 |
Molar Mass | 209.24 |
Storage Condition | 2-8°C |
In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
bioactivity | Aminooxy-PEG4-alcohol is a non-degradable ADC linker containing 4 units of PEG, it can be used to synthesize antibody-conjugated drugs (ADCS). Aminooxy-PEG4-alcohol is also a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. |