Alfuzosin hydrocholoride
Alfuzosine Hydrochloride
CAS: 81403-68-1
Molecular Formula: C19H28ClN5O4
Alfuzosin hydrocholoride - Names and Identifiers
Alfuzosin hydrocholoride - Physico-chemical Properties
| Molecular Formula | C19H28ClN5O4 |
| Molar Mass | 425.91 |
| Melting Point | 225°C |
| Boling Point | 687.7°C at 760 mmHg |
| Flash Point | 369.7°C |
| Solubility | DMSO: >10mg/mL |
| Vapor Presure | 3.75E-19mmHg at 25°C |
| Appearance | solid |
| Color | White to Off-White |
| Merck | 14,238 |
| pKa | 8.13(at 25℃) |
| Storage Condition | 2-8°C |
| MDL | MFCD00879135 |
| Physical and Chemical Properties | Crystallized from ethanol-diethyl ether, melting point 225 °c; Melting point 235 °c (decomposition). pKa 8.13. |
| Use | Alfuzosin HCl is an α1 receptor antagonist used in the treatment of benign prostatic hyperplasia (BPH). |
| In vitro study | Alfuzosin significantly increased the whole-cell sodium ion (hNa(v)1.5) peak current, increased the probability of late hNa(v)1.5 the opening of a single channel, and significantly shortened the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and opening per burst between 2-and 3-fold. In 10 mM phenylephrine precontracted rabbit corpuscavernosum(CC), Alfuzosin showed a concentration-dependent relaxing effect. |
| In vivo study | Alfuzosin(300 nM) significantly prolonged the action potential phase (APD) of rabbit Purkinje fibers (60) and QT of isolated rabbit hearts. In spontaneously hypertensive rats (SHR), Alfuzosin enhanced the number and amplitude of Apomorphine-induced erections. In spontaneously hypertensive rats (SHR), Alfuzosin behaves as an α-adrenergic receptor antagonist, blocking exogenous noradrenaline-induced contraction without altering vasdeferens vasoconstriction. In rats with spinal cord destruction, Alfuzosin(0.03-0.3 mg/kg, I. V.) significantly inhibited the pressor response produced by the α1-selective agonist, Cirazoline, but only slightly inhibited the response to the α2-selective agonist, UK 14,304. Alfuzosin(1 mg/kg, I. V.) had minimal effect on prejunctional α2-receptor stimulation-mediated responses (UK 14,304-induced inhibition of sympathetic tachycardia). In anesthetized cats, Alfuzosin(0.001 mg/kg, I. V.) and Prazosin(0.001-0.3 mg/kg, I. V.) produced a dose-related inhibition of sympathetic hypoabdominal nerve stimulation of the urethral pressure increase. |
Alfuzosin hydrocholoride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
| RTECS | LT9965475 |
| HS Code | 2934990002 |
Alfuzosin hydrocholoride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.348 ml | 11.74 ml | 23.479 ml |
| 5 mM | 0.47 ml | 2.348 ml | 4.696 ml |
| 10 mM | 0.235 ml | 1.174 ml | 2.348 ml |
| 5 mM | 0.047 ml | 0.235 ml | 0.47 ml |
Last Update：2024-01-02 23:10:35
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View History
Alfuzosin hydrocholoride
12-Hydroxystearic acid, methyl ester
1-(but-3-yn-2-yl)pyrrolidine, trifluoroacetic acid
Pilocarpine Hydrochloride EP Impurity C
8-Phenyl-1-thia-4-azaspiro[4.5]decan-3-one
2-[(4-Chlorosulphonyl)phenyl]pyrimidine, 2-[(4-Chlorosulphonyl)phenyl]-1,3-diazine
2-[(2-chlorophenyl)methanesulfonyl]-1-nitro-4-(trifluoromethyl)benzene
1-(PHENYLHYDRAZONE)OXANILOYL CHLORIDE
2-[(1-bromo-2-naphthyl)oxy]-N'-[2-(4-nitrophenoxy)acetyl]acetohydrazide
RUBIDIUM ATOMIC ABSORPTION STANDARD*SOLU TION
12-Hydroxystearic acid, methyl ester
1-(but-3-yn-2-yl)pyrrolidine, trifluoroacetic acid
Pilocarpine Hydrochloride EP Impurity C
8-Phenyl-1-thia-4-azaspiro[4.5]decan-3-one
2-[(4-Chlorosulphonyl)phenyl]pyrimidine, 2-[(4-Chlorosulphonyl)phenyl]-1,3-diazine
2-[(2-chlorophenyl)methanesulfonyl]-1-nitro-4-(trifluoromethyl)benzene
1-(PHENYLHYDRAZONE)OXANILOYL CHLORIDE
2-[(1-bromo-2-naphthyl)oxy]-N'-[2-(4-nitrophenoxy)acetyl]acetohydrazide
RUBIDIUM ATOMIC ABSORPTION STANDARD*SOLU TION