AZD0364
AZD0364
CAS: 2097416-76-5
Molecular Formula: C24H24F2N8O2
AZD0364 - Names and Identifiers
AZD0364 - Physico-chemical Properties
| Molecular Formula | C24H24F2N8O2 |
| Molar Mass | 494.5 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| Boling Point | 716.0±70.0 °C(Predicted) |
| Solubility | DMSO : 100 mg/mL (202.22 mM) |
| pKa | 2?+-.0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | Azd 0364 has high cellular activity on substrates directly downstream of the MAPK signaling pathway (as in BRAF. |
| In vivo study | Azd 0364 has good oral pharmacokinetics in various species. In a xenograft model, AZD0364 inhibits phosphorylated p90RSK1 in a concentration-dependent manner in tumors. AZD0634 induces tumor regression in a KRAS-mutated NSCLC Calu 6 xenograft model in which AZD0634 can be safely and effectively administered in combination with selumetinib. |
AZD0364 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.022 ml | 10.111 ml | 20.222 ml |
| 5 mM | 0.404 ml | 2.022 ml | 4.044 ml |
| 10 mM | 0.202 ml | 1.011 ml | 2.022 ml |
| 5 mM | 0.04 ml | 0.202 ml | 0.404 ml |
Last Update：2024-01-02 23:10:35
AZD0364 - Introduction
AZD0364 is an organic compound whose chemical name is 4-methyl-2-nitroaniline. The following is a description of the nature, use, formulation and safety information of AZD0364:
Nature:
-Appearance: AZD0364 usually appears in the form of white or light yellow crystals.
-Molecular formula: C7H8N2O2
-Molecular weight: 152.15g/mol
-Melting point: About 128-132 degrees Celsius
-Boiling point: about 344 degrees Celsius
-Solubility: AZD0364 can be dissolved in ethanol and ether and other organic solvents and insoluble in water.
Use:
- AZD0364 is a commonly used organic synthesis intermediate, which has a wide range of applications in the pharmaceutical and pesticide industries.
-In the field of medicine, AZD0364 is used in the synthesis of antibiotics, drugs and other pharmaceuticals.
-In the field of pesticides, AZD0364 is used in synthetic insecticides and herbicides.
Preparation Method:
-The preparation method of AZD0364 can be obtained by The nitration reaction of aniline. First, Aniline reacts with sulfuric acid and concentrated nitric acid to form nitrated aniline. The nitrated aniline is then subjected to a reduction reaction or other chemical transformation to give AZD0364.
Safety Information:
- AZD0364 is an organic compound, which needs to comply with relevant safety procedures when using and handling.
-It may be harmful to the human body and the environment, so avoid inhalation of gas, swallowing or skin contact when in contact.
-During use and storage, you need to ensure well-ventilated conditions and take appropriate personal protective measures, such as wearing gloves and goggles.
-If accidental exposure or ingestion occurs, seek medical assistance immediately and provide detailed information about the substance to the doctor.
Nature:
-Appearance: AZD0364 usually appears in the form of white or light yellow crystals.
-Molecular formula: C7H8N2O2
-Molecular weight: 152.15g/mol
-Melting point: About 128-132 degrees Celsius
-Boiling point: about 344 degrees Celsius
-Solubility: AZD0364 can be dissolved in ethanol and ether and other organic solvents and insoluble in water.
Use:
- AZD0364 is a commonly used organic synthesis intermediate, which has a wide range of applications in the pharmaceutical and pesticide industries.
-In the field of medicine, AZD0364 is used in the synthesis of antibiotics, drugs and other pharmaceuticals.
-In the field of pesticides, AZD0364 is used in synthetic insecticides and herbicides.
Preparation Method:
-The preparation method of AZD0364 can be obtained by The nitration reaction of aniline. First, Aniline reacts with sulfuric acid and concentrated nitric acid to form nitrated aniline. The nitrated aniline is then subjected to a reduction reaction or other chemical transformation to give AZD0364.
Safety Information:
- AZD0364 is an organic compound, which needs to comply with relevant safety procedures when using and handling.
-It may be harmful to the human body and the environment, so avoid inhalation of gas, swallowing or skin contact when in contact.
-During use and storage, you need to ensure well-ventilated conditions and take appropriate personal protective measures, such as wearing gloves and goggles.
-If accidental exposure or ingestion occurs, seek medical assistance immediately and provide detailed information about the substance to the doctor.
Last Update：2024-04-09 21:01:54
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View History
AZD0364
1261497-39-5
N-(3-chlorophenyl)-2-{[4-ethyl-5-(4-methoxybenzyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
Vitamin B1 Monophosphate Chloride
N-BOC-N,N-双(2-溴甲基)胺
1261497-39-5
N-(3-chlorophenyl)-2-{[4-ethyl-5-(4-methoxybenzyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
Vitamin B1 Monophosphate Chloride
N-BOC-N,N-双(2-溴甲基)胺