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ARV-771

ARV-771

CAS: 1949837-12-0

Molecular Formula: C49H60ClN9O7S2

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ARV-771 - Names and Identifiers

Name ARV-771
Synonyms ARV 771
ARV-771
ARV771
(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-
(2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CAS 1949837-12-0

ARV-771 - Physico-chemical Properties

Molecular FormulaC49H60ClN9O7S2
Molar Mass986.65
Density1.39±0.1 g/cm3(Predicted)
Solubility 10 mM in DMSO
pKa13.61±0.46(Predicted)
Storage ConditionSealed in dry,Store in freezer, under -20°C

ARV-771 - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.014 ml5.068 ml10.135 ml
5 mM0.203 ml1.014 ml2.027 ml
10 mM0.101 ml0.507 ml1.014 ml
5 mM0.02 ml0.101 ml0.203 ml
Last Update：2024-01-02 23:10:35

ARV-771 - Reference Information

biological activity ARV-771 is an effective pan-(bromodomain and extra-terminal)BET degradation agent, A new BET-PROTAC (protein-targeting chimera), for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2) have Kd values of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM, respectively.
TargetValue
BRD2-BD2 (Cell-free assay) 4.7 nM(Kd)
BRD3-BD2 (Cell-free assay) 7.6 nM(Kd)
BRD4-BD2 (Cell-free assay) 7.6 nM(Kd)
BRD3-BD1 (Cell-free assay) 8.3 nM(Kd)
BRD4-BD1 (Cell-free assay) 9.6 nM(Kd)
Use an effective BET degradant of the PROTAC class.
Last Update：2024-04-10 22:29:15
ARV-771
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MedChemExpress (MCE)
Spot supply
Product Name: ARV-771 Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
BOC Sciences
Spot supply
Product Name: ARV-771 Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: ARV-771 Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: ARV-771  Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: ARV-771 Visit Supplier Webpage Request for quotation
CAS: 1949837-12-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
ARV-771
Ethanol, 2-[(4,6-di-1-pyrrolidinyl-1,3,5-triazin-2-yl)amino]-
11-cis-13,14-Dihydro Retinol
Diphenyl[α-(2-piperidinoethyl)benzyl]phosphine oxide
4-chloro-N-{4-[(mesitylamino)sulfonyl]phenyl}benzamide
2-[(4,5-Diamino-1-naphthyl)azo]-5-nitrobenzenesulfonic acid
Benzoic acid, 5-mercapto-2-nitro-
rel-(3R,4S)-3-Amino-4-chlorotetrahydrothiophene 1,1-dioxide hydrochloride
128452-54-0
3-Desmethyl 4-Methyl Meclizine Dihydrochloride
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