Name | SKLB4771 |
Synonyms | AOB5016 SKLB477 SKLB4771 FLT3-IN-1 SKLB-4771 SKLB 4771 CHEMBL2046883 1-(5-(7-(3-morpholinopropoxy)quinazolin-4-ylthio)-1,3,4-thiadiazol-2-yl)-3-p-tolylurea N-(4-Methylphenyl)-N'-[5-[[7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]thio]-1,3,4-thiadiazol-2-yl]urea |
CAS | 1370256-78-2 |
Molecular Formula | C25H27N7O3S2 |
Molar Mass | 537.66 |
Density | 1.43±0.1 g/cm3(Predicted) |
Solubility | DMSO: ≥ 47 mg/mL |
pKa | 6.62±0.50(Predicted) |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.86 ml | 9.3 ml | 18.599 ml |
5 mM | 0.372 ml | 1.86 ml | 3.72 ml |
10 mM | 0.186 ml | 0.93 ml | 1.86 ml |
5 mM | 0.037 ml | 0.186 ml | 0.372 ml |
biological activity | SKLB4771 is a potent and selective human receptor tyrosine protein kinase FLT3 inhibitor, the IC50 was 10 μm. |
Target | Value |
FLT3 (Cell-free assay) | 10 nM |