AHSYB
Anhydrosafflor yellow B
CAS: 184840-84-4
Molecular Formula: C48H52O26
AHSYB - Names and Identifiers
AHSYB - Physico-chemical Properties
| Molecular Formula | C48H52O26 |
| Molar Mass | 1044.92 |
| Density | 1.88±0.1 g/cm3(Predicted) |
| Boling Point | 1462.3±65.0 °C(Predicted) |
| Solubility | Soluble in DMSO, Methanol and Pyridine |
| Appearance | Yellow powder |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | -20℃ |
AHSYB - Reference
| Reference Show more | 1. Huang Zhuangzhuang, Sun Yuhong, Xu Gang, etc. Evaluation of quality of Carthamus tinctorius L. In Xinjiang main producing areas by simultaneous determination of three components based on UPLC [J]. Chinese herbal medicines, 2018, 041(009):2150-2152. 2. Zhixiong Wang, Haofang Wan, Xin Tong, Yu He, Jihong Yang, Ling Zhang, Chongyu Shao, zhanding, haiton Wan, Chang Li, an integrated strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a mod 3. [IF=7.514] Xin Tong et al."Greener extraction process and enhanced in vivo bioavailability of bioactive components from Carthamus tinctorius L. by natural deep eutectic solvents."Food Chem. 2021 Jun;348:129090 4. [IF=6.529] Zhixiong Wang et al."An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model."Biomed Pharmacother. 2021 Jun;138:111451 5. [IF=4.411] Yangyang Zhang et al."Simultaneous Optimization of the Ultrasonic Extraction Method and Determination of the Antioxidant Activities of Hydroxysafflor Yellow A and Anhydrosafflor Yellow B from Safflower Using a Response Surface Methodology."Molecules. 2020 6. [IF=4.411] Zong-Jin Pu et al."The Comprehensive Evaluation of Safflowers in Different Producing Areas by Combined Analysis of Color, Chemical Compounds, and Biological Activity."Molecules. 2019 Jan;24(18):3381 |
AHSYB - Reference Information
| Overview | Carthamus tinctorius, also known as red-blue flowers, Carthamus tinctorius, is a dried tubular flower of plants belonging to the genus Carthamus Asteraceae. Carthamus tinctorius L. Is a traditional Chinese medicinal material, which was first published in "open Bao herbal medicine". "Compendium of Materia Medica" said safflower can "promoting blood circulation, dryness, pain, scattered swelling through. Traditional Chinese medicine that safflower flavor Xin, slightly bitter, warm, to the heart and liver meridian, with blood circulation, blood stasis and pain, blood pressure, blood fat, for closed, dysmenorrhea, traumatic injury, coronary heart disease, diseases such as angina pectoris and hypertension. Safflower in modern clinical prevention and treatment of coronary heart disease, myocardial infarction and cerebral thrombosis and other diseases of the important traditional Chinese medicine. Modern pharmacological experiments show that safflower can improve the blood oxygen supply of heart and brain, reduce ischemic injury, anticoagulant, anti-myocardial ischemia, inhibit platelet aggregation, antioxidant, anti-tumor and anti-inflammatory effects. The chemical composition of Carthamus tinctorius L. Is complex. Up to now, more than 100 compounds were isolated and identified from Carthamus tinctorius L., which mainly contain chalcones, flavonoids, phenolic acids, steroids and polysaccharides. Hydroxysafflor yellow A and dehydrated safflor yellow B(AHSYB) were the main active components in Carthamus tinctorius. However, the current research focused on hydroxysafflor yellow A, and there were few reports on the extraction process of AHSYB. |
| preparation | a method for extracting and purifying dehydrated safflower yellow B in safflower, characterized by comprising the following steps: 1) warm soaking Method: Place safflower in a closed container, add water 15-25 times the weight of safflower, soak at 55-85 ℃ for 26-38min, filter, the residues were added with water 9-13 times of the weight of the original medicinal herbs, soaked at 55-85 ℃ for 26-38min, filtered, combined with filtrate, and concentrated under reduced pressure to safflower water extract with concentration of 0.04-0.08g/mL; 2) pretreatment of macroporous adsorption resin: the HPD-300 type macroporous resin is placed in a beaker, soaked in 95% ethanol for 24h to fully swell, wash with ethanol through column until the eluate is not turbid by adding water, then wash with a large amount of water until there is no alcoholic taste, for standby use; 3) adsorption with macroporous resin: take the concentration of 0.04-0.08g/mL of safflower water extract, with dilute hydrochloric acid to adjust the sample solution pH 2.6-3.2, Flow rate 1.5-2.5/min through the HPD-300 type macroporous resin column, real-time monitoring of the effluent by HPLC, when the leakage is stopped; 4) macroporous resin elution: elution was carried out with ethanol with a concentration of 65-85%, the elution flow rate was controlled to 1.0-2.0/min, and the elution volume was 3-5BV, and the eluent was combined to obtain an eluent containing dehydrated safflower yellow B. |
| biological activity | anhydrosaflor yellow B (AHSYB) it is a quinolone C- glycoside isolated from Carthamus tintorius. Anhydrosafflor yellow B (AHSYB) inhibits ADP-induced platelet aggregation, has a significant antioxidant effect in vitro, and has anti-toxic activity on H2O2-induced PC12 cells and primary neuronal cells. |
Last Update：2024-04-09 02:00:12
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View History
AHSYB
2-羟基-5-(三氟甲基)烟碱醛
2-((3-CYANO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)-2-PYRIDINYL)THIO)ACETAMIDE
Urea, N'-[2-(diethylamino)ethyl]-N-methyl-N-(2-phenoxyethyl)-, hydrochloride (1:1)
Benzoic acid, p-hydroxy-, heptyl ester
对叔丁基苯甲酸乙烯酯
4-溴-2-氰基嘧啶
951946-24-0
2-甲基-4-吡啶羧酸
SALOR-INT L405353-1EA
2-羟基-5-(三氟甲基)烟碱醛
2-((3-CYANO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)-2-PYRIDINYL)THIO)ACETAMIDE
Urea, N'-[2-(diethylamino)ethyl]-N-methyl-N-(2-phenoxyethyl)-, hydrochloride (1:1)
Benzoic acid, p-hydroxy-, heptyl ester
对叔丁基苯甲酸乙烯酯
4-溴-2-氰基嘧啶
951946-24-0
2-甲基-4-吡啶羧酸
SALOR-INT L405353-1EA