AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS: 475221-20-6
Molecular Formula: C206H324N56O65
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 - Names and Identifiers
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 - Physico-chemical Properties
| Molecular Formula | C206H324N56O65 |
| Molar Mass | 4625.11 |
| Solubility | H2O: 1mg/mL |
| Appearance | solid |
| Color | white |
| Storage Condition | -20°C |
| In vivo study | NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies. Animal Model: 74 male Sprague-Dawley rats (328-377 g). Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO). Administration: IP, 15 min and 19 h post-injury. Result: Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 - Reference Information
| biological activity | NEP(1-40) is a peptide antagonist of Nogo-66 receptor (NgR), which reverses the changes in the morphological distribution of microglia caused by damage by inhibiting myelin. |
| in vivo study | NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies. Animal Model: 74 male Sprague-Dawley rats (328-377g). Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO). Administration: IP, 15 min and 19 h post-injury. Result: Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
| Animal Model: | 74 male Sprague-Dawley rats (328-377 g). |
| Dosage: | 89 μg/kg (97.5% PBS and 2.5% DMSO). |
| Administration: | IP, 15 min and 19 h post-injury. |
| Result: | Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: NEP(1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Nogo-66 (1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Nogo-66(1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: NEP(1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Nogo-66 (1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Nogo-66(1-40) Visit Supplier Webpage Request for quotationCAS: 475221-20-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
1,3-苯二甲酸与2,5-呋喃二酮、己二酸、1,3-异苯并呋喃二酮、2,2'-氧化双[乙醇]和1,2-丙二醇的聚合物
2-甲基丙-2-胺(S)-2-((叔-丁氧基羰基)氨基)-3-(呋喃-2-基)丙酸酯
Fentanyl Impurity 7 (Fentanyl EP Impurity G)
3-(4-溴苯基)-2-((叔丁氧基羰基)氨基)丙酸甲酯
Cyclopentanone, 2-(3-methyl-2-butenyl)-
POLY(2-ETHYLHEXYL ACRYLATE)
9-imino-1-oxa-9lambda6-thia-4-azaspiro[5.5]undecan-9-one dihydrochloride
4-((叔丁基二甲基甲硅烷基)氧基)-2-甲基苯甲酸甲酯
CHLOROMETHYL CYCLOHEXYL SULPHIDE
1,3-苯二甲酸与2,5-呋喃二酮、己二酸、1,3-异苯并呋喃二酮、2,2'-氧化双[乙醇]和1,2-丙二醇的聚合物
2-甲基丙-2-胺(S)-2-((叔-丁氧基羰基)氨基)-3-(呋喃-2-基)丙酸酯
Fentanyl Impurity 7 (Fentanyl EP Impurity G)
3-(4-溴苯基)-2-((叔丁氧基羰基)氨基)丙酸甲酯
Cyclopentanone, 2-(3-methyl-2-butenyl)-
POLY(2-ETHYLHEXYL ACRYLATE)
9-imino-1-oxa-9lambda6-thia-4-azaspiro[5.5]undecan-9-one dihydrochloride
4-((叔丁基二甲基甲硅烷基)氧基)-2-甲基苯甲酸甲酯
CHLOROMETHYL CYCLOHEXYL SULPHIDE