AC-PRO-HIS-SER-CYS-ASN-NH2
ATN-161
CAS: 262438-43-7
Molecular Formula: C23H35N9O8S
AC-PRO-HIS-SER-CYS-ASN-NH2 - Names and Identifiers
AC-PRO-HIS-SER-CYS-ASN-NH2 - Physico-chemical Properties
| Molecular Formula | C23H35N9O8S |
| Molar Mass | 597.64 |
| Density | 1.443±0.06 g/cm3(Predicted) |
| Boling Point | 1297.2±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 9.14±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | ATN-161 interaction with the N-terminus of the β1 region of integrin α5β1 locks integrin α5β1 in its inactive conformation. At concentrations up to 100 μm, ATN-161 had no significant effect on tumor cell proliferation. However, ATN-161 can significantly inhibit the phosphorylation of MAPK, and the maximum inhibition of MAPK phosphorylation can be detected at 30 minutes after treatment at a concentration of 20 μm. |
| In vivo study | ATN-161 (Ac-PHSCN-NH2) is a 5-mer capping peptide derived from the cooperative region of fibronectin, which binds to α5β1 and αvβ3 in vitro to prevent breast cancer growth and metastasis. ATN-161 treatment can cause a significant reduction in tumor volume, dose-dependently, and can completely prevent or cause a reduction in the number and incidence of bone and soft tissue metastases. ATN-161 treatment can also lead to a decrease in phosphorylated MAPK expression in vivo, a decrease in microvessel density and cell proliferation during tumor growth. ATN-161 has a relatively short half-life in plasma. The relatively long half-life in tumors suggests that the peptide plays a role in tumors through a long-lasting interaction with its target. |
AC-PRO-HIS-SER-CYS-ASN-NH2 - References
| biological activity | ATN-161 (Ac-PHSCN-NH2) is a small peptide antagonist of integrin α5β1. It is capable of binding several integrins, including α5β1 and αvβ3, to play a role in angiogenesis and tumor progression. |
| Target | Value |
Last Update：2024-04-09 20:52:54
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View History
AC-PRO-HIS-SER-CYS-ASN-NH2
2-PyriMidinaMine, 4-[2-[3-(2-furanyl)phenyl]ethyl]-6-(3-Methylbutoxy)-
4-溴-5-甲基-2-(三氟甲基)噻唑
2,3-双(4-羟基苯基)丙腈
2-(2-bromophenoxy)isonicotinamide
2-(3,5-二甲基异恶唑-4-基)乙醇
2-(4-ETHOXY-PHENOXY)-PROPIONIC ACID
Oxazole, 2-ethyl-5-[4-(methylthio)phenyl]-
1,5-Di-tert-butyl-3,3-dimethylbicyclo[3.1.0]hexan-2-one
N,N-二甲基乙胺
2-PyriMidinaMine, 4-[2-[3-(2-furanyl)phenyl]ethyl]-6-(3-Methylbutoxy)-
4-溴-5-甲基-2-(三氟甲基)噻唑
2,3-双(4-羟基苯基)丙腈
2-(2-bromophenoxy)isonicotinamide
2-(3,5-二甲基异恶唑-4-基)乙醇
2-(4-ETHOXY-PHENOXY)-PROPIONIC ACID
Oxazole, 2-ethyl-5-[4-(methylthio)phenyl]-
1,5-Di-tert-butyl-3,3-dimethylbicyclo[3.1.0]hexan-2-one
N,N-二甲基乙胺