Name | O-benzotriazol-1-yl-tetramethyluronium hexafluorophosphate |
Synonyms | HBTU O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-benzotriazol-1-yl-tetramethyluronium hexafluorophosphate O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM-HEXAFLUORO-PHOSPHATE O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate O-BENZOTRIAZOLE-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-(BENZOTRIAZOL-1-YL)-N-N-N ,N -TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE 2-(1h-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE POLYMER BOUND N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylidene]-N-methylmethanaminium hexafluorophosphate |
CAS | 94790-37-1 |
EINECS | 619-076-7 |
InChI | InChI=1/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1 |
InChIKey | UQYZFNUUOSSNKT-UHFFFAOYSA-N |
Molecular Formula | C11H16F6N5OP |
Molar Mass | 379.25 |
Melting Point | 200°C (dec.)(lit.) |
Flash Point | 200°C |
Solubility | acetonitrile: 0.1g/mL, clear |
Appearance | White Solid |
Color | White to Off-White |
BRN | 7328329 |
PH | 4.1 (1.6g/l, H2O) |
Storage Condition | Store at +2°C to +8°C. |
Stability | Stable. Incompatible with oxidizing agents. |
Sensitive | Easy to absorb moisture and sensitive to light |
MDL | MFCD00075445 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R42/43 - May cause sensitization by inhalation and skin contact. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10-21 |
HS Code | 29339980 |
Hazard Note | Irritant |
Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
Decomposition | 200 ºC |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | a condensing agent for polypeptide synthesis. peptide synthesis of coupling agents, the main advantages are: very low racemization, simple reaction conditions, short reaction time, high yield, the Crystal and Solution structure of the coupling agent is guanidinium Salt N-oxide, rather than urea cationic compound studies have shown that HBTU is guanidinium in either base crystal or solution state, the non-urea positive ion, when used as a polypeptide condensing agent, has the advantages of extremely low racemization probability, simple reaction conditions, short reaction time, and higher yield. |