946713-98-0 - Names and Identifiers
946713-98-0 - Physico-chemical Properties
Molecular Formula | C13H12FN
|
Molar Mass | 201.24 |
Storage Condition | Room Temprature |
Sensitive | Irritant |
MDL | MFCD08687851 |
946713-98-0 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Hazard Class | IRRITANT |
946713-98-0 - Introduction
2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine (2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine) is an organic compound with the chemical formula C14H12F-NH2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine is a white or off-white solid.
-Melting point: Its melting point range is usually between 75-80°C.
-Solubility: It has good solubility in some organic solvents such as ethanol, methanol and dichloromethane.
Use:
- 2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine is an important intermediate compound, which has a wide range of applications in pharmaceutical synthesis, organic synthesis and preparation of heterocyclic compounds. It can be used to synthesize biologically active compounds such as drugs, pesticides and dyes.
-It can also be used as a raw material for organic photoelectric materials.
Preparation Method:
2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine can be prepared by the following steps:
1. First synthesize 2 '-fluoro-[1,1'-biphenyl]-4-iodine: react [1,1 '-biphenyl]-2,2'-diphenol with hydrofluoric acid, and then pass Potassium nitrate and sodium sulfite generate the corresponding ester. The ester formed by the reaction is heated and decarboxylated to form-[1,1 '-biphenyl]-2,2'-dihydroxy, which is then oxidized with a bromic acid solution to form 2 '-fluoro-[1,1'-biphenyl]-4-iodo.
2. Preparation of 2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine: The target product can be obtained by reacting 2 '-fluoro-[1,1'-biphenyl]-4-iodide with methylamine.
Safety Information:
- 2 '-Fluoro-2-methyl[1,1'-biphenyl]-4-amine is a potentially dangerous organic compound. In the use and operation process, should follow the correct laboratory safety procedures.
-Avoid inhaling its dust or gas, avoid contact with skin and eyes. Good ventilation should be maintained in the working environment.
-Avoid contact with fire or high temperature. Store in a dry, cool place, away from oxidants and acids.
-Use personal protective equipment such as safety glasses, gloves and protective clothing to ensure safe operation. In case of accidental contact or inhalation, seek medical attention immediately.
Last Update:2024-04-09 02:00:57