Molecular Formula | C6H7BrN2 |
Molar Mass | 187.04 |
Density | 1.593±0.06 g/cm3(Predicted) |
Melting Point | 108-109℃ |
Boling Point | 283.5±35.0 °C(Predicted) |
Flash Point | 125.243°C |
Vapor Presure | 0.003mmHg at 25°C |
Appearance | Red crystal |
pKa | 4.53±0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.617 |
MDL | MFCD09031418 |
Risk Codes | 41 - Risk of serious damage to eyes |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
Hazard Class | IRRITANT |
use | aminopyridine is an important fine chemical intermediate and is widely used in the fields of medicine and pesticides. 2-methyl -3-amino -5-bromopyridine as mGluR2 antagonist, can be used in the treatment of central nervous system diseases. |
preparation | put reduced iron powder, acetic acid and water into 250mL four-port reaction bottle, heated and refluxed for 15min, cooled to 85 ℃, slowly added 2-methyl -3-nitro -5-bromopyridine, the reaction was exothermic, heated and refluxed for 1h after adding, and the reaction was complete, cooling to room temperature, suction filtration, filter residue washing, combining filtrates, adding sodium hydrosulfite to the filtrate to prevent the product from being oxidized, before proceeding to the next reaction, the solution is rotated and evaporated to obtain white-like powder 2-Methyl -3-amino -5-bromopyridine. |