Molecular Formula | C7H7NO3 |
Molar Mass | 153.14 |
Density | 1.263±0.06 g/cm3(Predicted) |
Melting Point | 211-212 °C |
Boling Point | 342.4±42.0 °C(Predicted) |
Flash Point | 160.9°C |
Vapor Presure | 7.53E-05mmHg at 25°C |
pKa | 11.02±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.517 |
Hazard Symbols | Xi - Irritant |
UN IDs | UN2811 |
Hazard Note | Irritant |
introduction | pyridine is an aromatic nitrogen-containing compound. pure pyridine is relatively small in nature. pyridine for industrial use is generally synthesized by shrinking into a ring, so the cost of raw materials is relatively high. Methyl 2-hydroxypyridine-4-carboxylate is one of the pyridine compounds. It is composed of (R)-2-thiotetrahydrothiazol-4-carboxylic acid and methanol and dichlorothionyl. The yield is 98%, and it is mainly used as a pharmaceutical intermediate. |
Uses | 2-hydroxypyridine-4-carboxylate methyl ester is an ester derivative, mainly used as a pharmaceutical intermediate. |
preparation | 10g( 0.066mol) of m-nitrobenzaldehyde, 11g(o.067mol) of chloroethyl acylacetate are dissolved in 60ml of benzene and 1ml of human piperidine is added. 1ml of glacial acetic acid is heated in a water bath, and the water generated in the reaction is continuously removed by Dean-start water separator. After refluxing for 3 hours, the benzene is steamed out, 20ml of diethyl ether is added to the remaining, frozen, crystallized, suction filtration, and dried to obtain 16.2g of 2-hydroxypyridine -4-carboxylic acid methyl ester with a yield of 82% ,mp 92-96 ℃. |