Name | 2-Hydroxybenzeneboronic acid |
Synonyms | AKOS BRN-0196 2-Boronophenol RARECHEM AH PB 0223 2-Hydroxyphenylboronic 2-HYDROXYPHENYLBORONIC ACID O-HYDROXYPHENYLBORONIC ACID 2-Hydroxyphenylboronic acid 2-HYDROXYBENZENEBORONIC ACID 2-Hydroxybenzeneboronic acid 2-Boronophenol~2-Hydroxyphenylboronic acid |
CAS | 89466-08-0 |
EINECS | 677-277-5 |
InChI | InChI=1/C6H7BO3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8-10H |
Molecular Formula | C6H7BO3 |
Molar Mass | 137.93 |
Density | 1.32±0.1 g/cm3(Predicted) |
Melting Point | 178-182°C |
Boling Point | 327.3±44.0 °C(Predicted) |
Flash Point | 151.7°C |
Water Solubility | Insoluble in water. |
Solubility | Acetonitrle (Slightly), DMSO (Slightly) |
Vapor Presure | 8.28E-05mmHg at 25°C |
Appearance | Crystalline powder |
Color | White |
BRN | 2962938 |
pKa | 8.61±0.58(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.582 |
MDL | MFCD01074581 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
HS Code | 29319000 |
Hazard Class | IRRITANT |
Introduction | 2-hydroxyphenylboronic acid is an important molecular fragment for the preparation of new drugs for the treatment of diabetes, it is also an important intermediate in organic synthesis of pharmaceuticals and pesticides. It is widely used in Suzuki cross-coupling reaction and is a key intermediate in the preparation of 2-hydroxybiphenyl compounds. Suzuki-Miyaura coupling reaction (SMC) is an important reaction to construct all kinds of C- C single bonds, and its main raw material is organic boric acid compound. |
Application | 2-hydroxyphenylboronic acid is a boronizing reagent, which can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process. |