875318-46-0

875318-46-0 - Names and Identifiers

Name	ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate
Synonyms	ethyl 2-[4-(hydroxymethyl)-1-piperidyl]pyrimidine-5-carboxylate ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate 5-Pyrimidinecarboxylic acid, 2-[4-(hydroxymethyl)-1-piperidinyl]-, ethyl ester
CAS	875318-46-0
InChI	InChI=1S/C13H19N3O3/c1-2-19-12(18)11-7-14-13(15-8-11)16-5-3-10(9-17)4-6-16/h7-8,10,17H,2-6,9H2,1H3

875318-46-0 - Physico-chemical Properties

Molecular Formula	C13H19N3O3
Molar Mass	265.30826
Density	1.2±0.0 g/cm3
Boling Point	447.7±0.0 °C at 760 mmHg
Flash Point	224.6±0.0 °C
Vapor Presure	0.0±0.0 mmHg at 25°C
pKa	14.94±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.545

875318-46-0 - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29335990

875318-46-0 - Introduction

Ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate is an organic compound with the chemical formula C14H20N4O3.

Nature:
-Appearance: colorless or light yellow liquid
-Melting point: No data
-Boiling Point: No data
-Density: No data
-Solubility: Soluble in organic solvents, such as ethanol, toluene

Use:
- ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate is a pharmaceutical intermediate. It can be used to synthesize biologically active compounds, such as drugs in the field of medicine.

Preparation Method:
- ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate can be synthesized by the following steps:
1. The methyl piperidine is reacted with acetic anhydride to obtain N acetyl -4-methyl piperidine.
2. N-acetyl -4-methyl piperidine is reacted with hydrocyanic acid ester to obtain N-formyl-N-(4-methylpiperidin-1-yl) carboxamide.
3. Reaction of N-formyl-N-(4-methylpiperidin-1-yl) carboxamide with ethyl 2-bromoacetate to give ethyl 2-(4-methylpiperidin-1-yl) acetate.
4. Finally, 2-(4-methylpiperidin-1-yl) ethyl acetate is reacted with uracil to obtain the final product ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate.

Safety Information:
- ethyl 2-[4-(hydroxymethyl)piperidin-1-yl]pyrimidine-5-carboxylate need to be stored in a cool, ventilated place.
-Avoid inhaling, chewing or eating during use.
-Avoid contact with skin, eyes or mucous membranes. In case of contact, rinse immediately with plenty of water.
-Wear personal protective equipment such as gloves and goggles during use.
-When handling or disposing of the compound, the relevant local, national and international safety practices and laws and regulations should be followed.

Last Update：2024-04-09 21:00:56