870777-29-0 - Names and Identifiers
870777-29-0 - Physico-chemical Properties
Molecular Formula | C8H8BFO3
|
Molar Mass | 181.96 |
Density | 1.28±0.1 g/cm3(Predicted) |
Melting Point | 112-117 °C (lit.) |
Boling Point | 376.1±52.0 °C(Predicted) |
Flash Point | 181.3°C |
Vapor Presure | 2.52E-06mmHg at 25°C |
pKa | 7.54±0.58(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.515 |
870777-29-0 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
WGK Germany | 3 |
HS Code | 29310095 |
Hazard Class | IRRITANT |
870777-29-0 - Introduction
(5-acetyl-2-fluorophenyl)boronic acid is an organic compound with the chemical formula C8H8BFO3. It is a white crystalline solid which is soluble in organic solvents such as chloroform, dimethyl sulfoxide and ethanol.
(5-acetyl-2-fluorophenyl)boronic acid is commonly used in Cross-Coupling reactions in organic synthesis, especially Suzuki reactions. In a Suzuki reaction, it can react with an organohalide to form the corresponding arylborate product. These aryl boronic acid esters have a wide range of applications in organic synthesis and can be used as important intermediates for the construction of aromatic and heterocyclic rings.
The method for preparing (5-acetyl-2-fluorophenyl)boronic acid is generally obtained by reacting sodium borohydride with 5-acetyl-2-fluorobenzoic acid. First, 5-acetyl -2-fluorobenzoic acid is dissolved in THF solvent, and then excess sodium borohydride is added. The reaction process generally needs to be carried out under the protection of inert gas, and is heated to reflux for several hours. After the reaction, the THF solvent is removed, and the resulting product can be crystallized and purified to obtain a pure product.
Regarding safety information,(5-acetyl-2-fluorophenyl)boronic acid should be handled in a well-ventilated environment, avoiding inhalation, contact with skin and eating. During use, it is recommended to wear appropriate personal protective equipment, such as gloves, glasses and laboratory coats. At the same time, please store in a dry, cool place, and avoid contact with oxygen, air, oxidants and other harmful substances.
Last Update:2024-04-10 22:29:15