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868540-17-4

Carfilzomib

CAS: 868540-17-4

Molecular Formula: C40H57N5O7

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868540-17-4 - Names and Identifiers

Name Carfilzomib
Synonyms PR 171
PX-171-007
Carfilzomib
CarfilzoMib salt
PR-171 (CarfilzoMib)
Carfilzomib API and intermediates
(alphaS)-alpha-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide
N-{(2S)-2-[(Morpholin-4-ylacetyl)aMino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninaMide
N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl}-L-phenylalaninamide
(S)-2-((S)-2-(2-(2H-1,4-oxazin-4(3H)-yl) acetamido)-4-phenylbutanamide)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pentanamide
CAS 868540-17-4
EINECS 692-054-2
InChI InChI=1/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

868540-17-4 - Physico-chemical Properties

Molecular FormulaC40H57N5O7
Molar Mass719.92
Density1.161
Melting Point204 - 208°C
Boling Point975.6±65.0 °C(Predicted)
Flash Point543.8℃
Solubility Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).
Vapor Presure0mmHg at 25°C
Appearancesolid
ColorWhite
pKa13.17±0.46(Predicted)
Storage Condition-20°
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Refractive Index1.551
UseProteasomel inhibitors, analogs of epoxomicin

868540-17-4 - Risk and Safety

HS Code29337900

868540-17-4 - Introduction

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 <5 nM. It preferentially inhibits the ChT-L activity of β5 subunit in vitro and has little or no effect on PGPH and T-L activities.
Last Update：2022-10-16 17:29:27
868540-17-4
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CAS: 868540-17-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Carfilzomib Visit Supplier Webpage Request for quotation
CAS: 868540-17-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
868540-17-4
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