84633-29-4
Eurycomanone
CAS: 84633-29-4
Molecular Formula: C20H24O9
84633-29-4 - Names and Identifiers
84633-29-4 - Physico-chemical Properties
| Molecular Formula | C20H24O9 |
| Molar Mass | 408.4 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Melting Point | 273-285℃ (methanol ethyl ether ) |
| Boling Point | 669.5±55.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White crystalline powder |
| Color | Off-White to Pale Beige |
| pKa | 11.29±0.70(Predicted) |
| Storage Condition | -20°C Freezer |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dongge Ali. |
| In vitro study | Eurycomanone (EN) significantly increased testosterone production dose-dependently at 0.1, 1.0 and 10.0 μM, but the two lower doses when combined with 3-isobutyl-1-methylxanthine (IBMX), the phosphodiesterase inhibitor were not significantly higher than EN or IBMX alone, except at a higher concentration. The molecular docking studies indicated EN and IBMX were binding at different sites of the enzyme. EN has no reversal of inhibition by aminoglutethimide, ketoconazole or nifedipine at the respective steroid oogenesis enzyme. The quassinoid was also non-responsive to the inhibition of oestrogen receptor by tamoxifen, but displayed improved for mestane inhibition of aromatase in reducing oestrogen production. The molecular docking studies further supported that EN and formestane bound to aromatase with similar orientations and free energy binding values. |
84633-29-4 - Reference
| Reference Show more | 1. Zhang Lihua, Zhang Yuefen, Tang Xiaolun. Aqueous two-phase system extraction of Dongge Ali and preparation of dropping pills [J]. Chinese Journal of Hospital Pharmacy, 2020,40(22):2308-2312. |
84633-29-4 - Reference Information
| Plant Source: | Dongge Ali |
| Introduction | a plant of Simarubaceae, Eurycoma longifolia Jack, English name: Ali's Umbrella, alias: the staff of Ali, donggeyali, maleic ginseng, natural aphrodisiac, the Earth, the King of the forest, the medicine for treating all diseases, etc. It is a kind of wild shrub plant growing in the moist sandy soil of the primitive tropical rain forest near the equator in Southeast Asia. The root of Dongge Ali has a variety of functions, together with the Bird's Nest and the tin ware, and is called the three national treasure of Malaysia. The main chemical components of donggejali extract are: fluorenone, antioxidant enzymes, alkaloids, various β-carbolines (canthine-6-one alkaloids) material, dead wood bitter pigment, etc. Broad tryptanthrin molecular formula: C20H24O9, molecular weight 408.4, density: 1.63g/cm3, Boiling Point: 669.5 ° C, Flash point: 239.9 ° C, refractive index: 1.684, belonging to the steroid. The main active ingredient of Dongge Ali is the compound of the bitter lignin, and the broad fluorenone (EN) is the most representative. At present, the application in health care products, drugs are low content or proportion of products, the future in order to achieve better results, the need for higher content of broad fluorenone. |
| physiological function | 1) anti-depression, anti-fatigue, improve physical fitness, maintain vigorous energy. 2) strengthen human blood circulation and metabolism, reduce the risk of heart disease and myocardial infarction. 3) improve the ability of autoimmunity, anti-virus, anti-malaria, can be used as anti-cancer and anti-AIDS adjuvant therapy. 4) relieve the symptoms of metabolic diseases such as diabetes, hypertension, gout and rheumatism. 5) promote the body's own secretion of testosterone, promote the growth of human muscle. 6) improve frigidity, improve the sexual ability of the elderly, extend the time of sex, increase the frequency of sex and pleasure, and quickly restore physical strength after sex. 7) repair and nourishing the human gonad, reproductive system, to eliminate the symptoms of prostatitis effect is remarkable. 8) improve male sperm production, improve sperm activity and improve fertility. 9) antioxidant, anti-aging, improve cognitive ability, reduce the risk of Alzheimer's disease. 10) delay menopause, postpartum tonic, accelerate uterine contraction. 11) regulate endocrine system, anti-ulcer, anti-allergic reaction, antipyretic, analgesic, tuberculosis, jaundice, etc. |
| biological activity | Eurycomanone can promote spermatogenesis by inhibiting the activities of phosphodiesterase and aromatase during estrogen production. |
| Use | broad fluorenone has the advantages of malaria truncation, removing dampness and removing yellow, strengthening Yang, enhancing physical strength and vitality, reducing fatigue, bactericidal, anti-ulcer, antipyretic efficacy. for content determination/identification/pharmacological experiments, etc |
Last Update：2024-04-09 21:01:54
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View History
84633-29-4
1245-15-4
[1-(3-chloro-4-fluorophenyl)ethyl][2-(dimethylamino)-2-(furan-2-yl)ethyl]amine
N,N-DIETHYL-N'-(6-METHYL-1,3-BENZOTHIAZOL-2-YL)ETHANE-1,2-DIAMINE
(20S)-20-Hydroxy-3,6-dioxo-5α-pregnan-18-oic acid γ-lactone
Oxazole, 2-(3,4-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyl-
Furan-2,3-dicarboxylic acid dimethyl ester
3-Pyridinecarbonitrile, 6-(1,1-dimethoxyethyl)-1,2-dihydro-2-thioxo-
898790-56-2
1-Isoquinolineacetic acid, 1,2,3,4-tetrahydro-2-(methylsulfonyl)-
1245-15-4
[1-(3-chloro-4-fluorophenyl)ethyl][2-(dimethylamino)-2-(furan-2-yl)ethyl]amine
N,N-DIETHYL-N'-(6-METHYL-1,3-BENZOTHIAZOL-2-YL)ETHANE-1,2-DIAMINE
(20S)-20-Hydroxy-3,6-dioxo-5α-pregnan-18-oic acid γ-lactone
Oxazole, 2-(3,4-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyl-
Furan-2,3-dicarboxylic acid dimethyl ester
3-Pyridinecarbonitrile, 6-(1,1-dimethoxyethyl)-1,2-dihydro-2-thioxo-
898790-56-2
1-Isoquinolineacetic acid, 1,2,3,4-tetrahydro-2-(methylsulfonyl)-