Fmoc-(R)-3-Amino-4-(2-bromo-phenyl)-butyric acid is an organic compound with the chemical formula C22H19BrNO4. The following is a description of its nature, use, preparation and safety information:
Nature:
Fmoc-(R)-3-Amino-4-(2-bromo-phenyl)-butyric acid is a white solid with high melting point and thermal stability. It is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane. The compound is a chiral compound and exists in the (R)-configuration.
Use:
Fmoc-(R)-3-Amino-4-(2-bromo-phenyl)-butyric acid is a protecting group commonly used in solid phase synthesis. It can be used as a protecting group of amino acids for the synthesis of polypeptides and proteins. The Fmoc group can provide protection to the amino acid during solid phase synthesis and, if desired, release the amino acid by a protection reaction.
Preparation Method:
Fmoc-(R)-3-Amino-4-(2-bromo-phenyl)-butyric acid can be obtained by reacting Fmoc-(R)-3-amino-4-hydroxybutyric acid with bromobenzene. Specific synthetic methods can refer to the relevant synthetic literature and chemical handbooks.
Safety Information:
Fmoc-(R)-3-Amino-4-(2-bromo-phenyl)-butyric acid needs to pay attention to safety measures during operation. It may be irritating to the eyes, skin and respiratory tract. Therefore, it is necessary to wear appropriate protective equipment, such as laboratory gloves and goggles, when in use. At the same time, the laboratory should be kept well ventilated and avoid breathing its vapors. If it comes into contact with skin or eyes, rinse immediately with plenty of water. If necessary, seek medical attention and carry packaging or labels for disposal. During storage, contact with oxidants and strong acids should be avoided to maintain good sealing.