76041-79-7

76041-79-7 - Names and Identifiers

Name	5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine
Synonyms	5-BROMO-3-TRIFLUOROMETHYL-2-PYRIDONE 2-hydroxy-5-broMo-3-trifluoropyridine 5-Bromo-3-(trifluoromethyl)pyridin-2-ol 5-BroMo-3-trifluoroMethyl-1H-pyridin-2-one 5-broMo-3-(trifluoroMethyl)-2(1H)-pyridinone 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, 5-Bromo-2-hydroxy-alpha,alpha,alpha-trifluoro-3-picoline
CAS	76041-79-7

76041-79-7 - Physico-chemical Properties

Molecular Formula	C6H3BrF3NO
Molar Mass	241.99
Density	1.876±0.06 g/cm3(Predicted)
Boling Point	229.4±40.0 °C(Predicted)
Flash Point	92.5 °C
Appearance	Solid
pKa	7.61±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

76041-79-7 - Introduction

5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is an organic compound whose chemical formula is C6H3BrF3NO. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is a colorless to light yellow solid.
-Melting point: Its melting point is about 72-74°C.
-Boiling point: Its boiling point is about 170-176 ℃.
-Solubility: The compound is soluble in common organic solvents, such as ethanol, ether and dichloromethane.

Use:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is often used as a catalyst in organic synthesis reactions, and is widely used in the construction of carbon-fluorine bonds and other key organic syntheses.
-Due to its application in organic synthesis, 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is an important intermediate for the synthesis of other organic compounds.

Preparation Method:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine can be obtained by reacting 3-bromopyridine with trifluoromethyl alcohol in the presence of a base.
-In the reaction process, 3-bromopyridine and trifluoromethyl alcohol are first reacted to generate an intermediate, and then the elimination reaction is carried out by adding a base catalyst to generate the final product.

Safety Information:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is relatively safe under correct use and operation, but the following matters still need to be paid attention:
-The compound may be irritating to the eyes and skin and should be avoided.
-Avoid inhaling its odor or dust during operation, and operate in a well-ventilated place.
-When storing and handling the compound, observe the relevant safety procedures and pay attention to the risk of fire and explosion.

Last Update：2024-04-10 22:29:15