5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is an organic compound whose chemical formula is C6H3BrF3NO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is a colorless to light yellow solid.
-Melting point: Its melting point is about 72-74°C.
-Boiling point: Its boiling point is about 170-176 ℃.
-Solubility: The compound is soluble in common organic solvents, such as ethanol, ether and dichloromethane.
Use:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is often used as a catalyst in organic synthesis reactions, and is widely used in the construction of carbon-fluorine bonds and other key organic syntheses.
-Due to its application in organic synthesis, 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is an important intermediate for the synthesis of other organic compounds.
Preparation Method:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine can be obtained by reacting 3-bromopyridine with trifluoromethyl alcohol in the presence of a base.
-In the reaction process, 3-bromopyridine and trifluoromethyl alcohol are first reacted to generate an intermediate, and then the elimination reaction is carried out by adding a base catalyst to generate the final product.
Safety Information:
- 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine is relatively safe under correct use and operation, but the following matters still need to be paid attention:
-The compound may be irritating to the eyes and skin and should be avoided.
-Avoid inhaling its odor or dust during operation, and operate in a well-ventilated place.
-When storing and handling the compound, observe the relevant safety procedures and pay attention to the risk of fire and explosion.