Molecular Formula | C13H12FN3O2 |
Molar Mass | 261.25 |
Density | 1.305 |
Melting Point | 143 °C |
Boling Point | 459.8±45.0 °C(Predicted) |
Flash Point | 231.9°C |
Solubility | Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly) |
Vapor Presure | 1.22E-08mmHg at 25°C |
Appearance | Solid |
Color | Orange to Dark Red to Brown |
pKa | 13.92±0.46(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.602 |
Use | 4-(4-amino-3-fluorophenoxy) methylamine pyridine-2-carboxylate is an organic intermediate, which is commonly used as an intermediate of antitumor drugs. |
preparation | 4-(4-amino-3-fluorophenoxy) pyridine-2-carboxylic acid methylamine can be prepared by a one-step reaction from 4-amino-3-fluorophenol and 4-chloro-n-methylpyridine-2-carboxamide as starting materials. 4-amino-3-fluorophenol (1.27g,10mmol,1.0eq) was added to dried DMF(20ml) and stirred well. Potassium tert-butoxide (1.34g,12mmol,1.0eq) was added and stirred under nitrogen at room temperature for 1H. 4-chloro-n-methylpyridine-2-carboxamide (1.70g,10mmol,1.0eq), heating to 85 deg C to continue the reaction for 10 hours. The reaction solution was quenched with water (100mL), and then extracted with dichloromethane (200mL * 2). The organic phase was dried over anhydrous magnesium sulfate, and the organic phase was spin-dried to obtain an oily liquid, column chromatography (petroleum ether: ethyl acetate = 4:1) was performed to obtain 4-(4-amino-3-fluorophenoxy) pyridine-2-carboxylic acid methylamine (1.3g). |