752-56-7
Vitamin B2 Tetrabutyrate
CAS: 752-56-7
Molecular Formula: C33H44N4O10
752-56-7 - Names and Identifiers
| Name | Vitamin B2 Tetrabutyrate |
| Synonyms | hibon Riboflavinebutyrate VITAMIN B2 TETRABUTYRATE Vitamin B2 Tetrabutyrate RIBOFLAVIN TETRABUTYRATE RIBOFLAVINE TETRABUTYRATE riboflavin,2',3',4',5'-tetrabutyrate riboflavin,2',3',4',5'-tetrabutanoate [(2S,3S,4R)-3,4,5-tri(butanoyloxy)-1-(7,8-dimethyl-2,4-dioxo-benzo[g]pteridin-10-yl)pentan-2-yl] butanoate |
| CAS | 752-56-7 |
| EINECS | 212-034-5 |
752-56-7 - Physico-chemical Properties
| Molecular Formula | C33H44N4O10 |
| Molar Mass | 656.72 |
| Density | 1.250 g/cm3 |
| Melting Point | 149 °C |
| Solubility | DMSO (Slightly), Methanol (Sparingly) |
| Appearance | Solid |
| Color | Yellow |
| Merck | 14,8200 |
| pKa | 9.83±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| MDL | MFCD00059691 |
| In vitro study | Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction. |
| In vivo study | Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver . |
752-56-7 - Risk and Safety
| RTECS | VJ1755000 |
752-56-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.523 ml | 7.614 ml | 15.227 ml |
| 5 mM | 0.305 ml | 1.523 ml | 3.045 ml |
| 10 mM | 0.152 ml | 0.761 ml | 1.523 ml |
| 5 mM | 0.03 ml | 0.152 ml | 0.305 ml |
Last Update：2024-01-02 23:10:35
752-56-7 - Reference Information
| identification test | Sample 1mg, dissolved in ethanol, should be light yellow-green, with strong yellow-green fluorescence, when dilute hydrochloric acid (TS-117) or sodium hydroxide solution (TS-224) was added, the fluorescence disappeared. Take 10 mg of sample and dissolve in 5ml of ethanol, add 2ml of 1:1 mixture of 15% hydroxylamine hydrochloride solution and 15% sodium hydroxide solution, shake well, then add 0. 8ml hydrochloric acid and 0. 5ml ferric chloride solution (TS-101). And equal volume of ethanol, should be dark red-brown. |
| content analysis | after drying the sample in a vacuum dryer (sulfuric acid) for 4H, weigh accurately about 40mg, dissolve in ethanol and dilute to 500 ml, take 10ml, add ethanol to 50ml, as a sample solution. This was stored in a 1cm Cuvette, and the absorbance A1 at a wavelength of 445nm was measured, and ethanol was used as a control solution. After drying standard riboflavin at 105 ℃ for 3H, weigh about 50mg accurately, add 4ml of glacial acetic acid and ml of water mixture, heat and dissolve, add water to ML after cooling. 5ml of this solution was taken, and ethanol was added to 50ml, which was used as a standard solution. In the same manner as the sample solution, the absorbance A2 of the standard solution at a wavelength of 445nm was measured, and the content of riboflavin tetrabutyrate (C33H44O10N4) was obtained according to the following formula. Content (%) =(A1/A2)×[25X1.745/pattern (mg)]× 100 |
| toxicity | very low toxicity. LD50>15g/kg (mouse, oral). Rats were given 500 ~ 2000mg/kg for 6 months, no significant change. |
| usage limit | GB 14880-94: same as "01022, Riboflavin". |
| biological activity | ribovin flavantebutyrate is a lipophilic Flavin derivative with antioxidant and lipid peroxide removal activity. |
Last Update：2024-04-09 02:00:13
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View History
752-56-7
N-(3,4-difluorophenyl)-2-fluorobenzamide
Butane-1,2,3-tricarboxylic acid 1-(2-hydroxyethyl)2,3-dihexyl ester
(R)-4-Hydroxy-α-[[(Z)-3-methoxy-1-methyl-3-oxo-1-propenyl]amino]benzeneacetic acid potassium salt
ethyl 5-(4-hydroxyphenyl)-2-(4-isopropoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
3-Quinolinecarboxylicacid, 4-[[2-(dipropylamino)-1-methyl-2-oxoethyl]amino]-7-(trifluoromethyl)-,ethyl ester
4-(2,3,3-trimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate
N-(3,4-difluorophenyl)-2-fluorobenzamide
Butane-1,2,3-tricarboxylic acid 1-(2-hydroxyethyl)2,3-dihexyl ester
(R)-4-Hydroxy-α-[[(Z)-3-methoxy-1-methyl-3-oxo-1-propenyl]amino]benzeneacetic acid potassium salt
ethyl 5-(4-hydroxyphenyl)-2-(4-isopropoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
3-Quinolinecarboxylicacid, 4-[[2-(dipropylamino)-1-methyl-2-oxoethyl]amino]-7-(trifluoromethyl)-,ethyl ester
4-(2,3,3-trimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate