724453-98-9
1-(4-(benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea
CAS: 724453-98-9
Molecular Formula: C22H17Cl2N3O2S
724453-98-9 - Names and Identifiers
| Name | 1-(4-(benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea |
| Synonyms | Diflapolin 1-(4-(benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea Urea, N-[4-(2-benzothiazolylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)- 1-(4-(Benzo[d]thiazol-2-ylmethoxy)-2-methylphenyl)-3-(3,4-dichlorophenyl)urea N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea |
| CAS | 724453-98-9 |
724453-98-9 - Physico-chemical Properties
| Molecular Formula | C22H17Cl2N3O2S |
| Molar Mass | 458.36 |
| Storage Condition | -20℃ |
| Use | Diflapolin is a potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor. It inhibits formation of the 5-lipoxygenase (5-LO) products leukotriene B4 (LTB4) and 5-HpETE in isolated human monocytes and neutrophils (IC50s = 30 and 170 nM, respectively) and inhibits the epoxide hydrolase activity of sEH with an IC50 value of 20 nM in a cell-free assay. |
724453-98-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.182 ml | 10.909 ml | 21.817 ml |
| 5 mM | 0.436 ml | 2.182 ml | 4.363 ml |
| 10 mM | 0.218 ml | 1.091 ml | 2.182 ml |
| 5 mM | 0.044 ml | 0.218 ml | 0.436 ml |
Last Update：2024-01-02 23:10:35
724453-98-9 - Animal Experiment
1: Vieider L, Romp E, Temml V, Fischer J, Kretzer C, Schoenthaler M, Taha A, Hernández-Olmos V, Sturm S, Schuster D, Werz O, Garscha U, Matuszczak B. Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors. ACS Med Chem Lett. 2018 Nov 29;10(1):62-66. doi: 10.1021/acsmedchemlett.8b00415. PMID: 30655948; PMCID: PMC6331193.2: Garscha U, Romp E, Pace S, Rossi A, Temml V, Schuster D, König S, Gerstmeier J, Liening S, Werner M, Atze H, Wittmann S, Weinigel C, Rummler S, Scriba GK, Sautebin L, Werz O. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017 Aug 24;7(1):9398. doi: 10.1038/s41598-017-09795-w. PMID: 28839250; PMCID: PMC5571211.
Last Update：2023-08-16 21:32:38
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