Molecular Formula | C10H9NO |
Molar Mass | 159.18 |
Density | 1.226±0.06 g/cm3(Predicted) |
Melting Point | 206-208°C |
Boling Point | 341.0±22.0 °C(Predicted) |
Appearance | Yellow crystal |
BRN | 122340 |
pKa | 15.80±0.30(Predicted) |
Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
Sensitive | Air Sensitive |
MDL | MFCD00047170 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. |
WGK Germany | 3 |
HS Code | 29339900 |
Hazard Note | Irritant |
Introduction | 7-methyl indole -3-formaldehyde is a kind of indole -3-formaldehyde compounds. Indole is the most widely distributed nitrogen-containing heterocyclic compounds in nature. Indole compounds widely exist in natural products, clinical drugs, dyes and luminescent materials. Indole is easy to occur in the C- 3 derivative reaction, and indole C- 3 derivatives have a variety of reactivity, and aldehyde compounds are important intermediates in organic synthesis, aldehyde group is prone to C- C or C- N coupling reaction, oxidation reaction and reduction reaction, therefore, the introduction of aldehyde group in the C- 3 position of indole is an important method for direct functionalization of indole, it is one of the important strategies for the further synthesis of indole-containing derivatives. |
Application | 7-methylindole-3-carboxaldehyde can be used as an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
preparation | phosphorus oxychloride is dissolved in DMF solution, stirred in an ice bath and cooled to about 0 ℃, after 7-methyl indole is dissolved in DMF solution, it is added to the above solution, and the reaction is naturally restored to room temperature, followed by TLC Detection. After the reaction is completed, ice water is added under ice water cooling, then 30% NaOH aqueous solution is adjusted to pH 8~9, Reflux reaction, the reaction liquid is poured into water and stirred until solidification, filter cake is recrystallized with methanol to obtain 7-methyl indole -3-formaldehyde. |