Name | 7-bromoisoindolin-1-one |
Synonyms | 7-Bromoisoindolinone 7-Bromo-1-isoindolinone 7-bromoisoindolin-1-one 7-Bromo-2,3-dihydro-isoindol-1-one 7-bromo-2,3-dihydro-isoindole-1-one 7-bromo-2,3-dihydro-1H-isoindol-1-one 7-broMo-2,3-dihydro-1H-isoindol-1-one 1H-Isoindol-1-one, 7-broMo-2,3-dihydro- 1H-Isoindol-1-one, 7-bromo-2,3-dihydro- |
CAS | 200049-46-3 |
InChI | InChI=1/C8H6BrNO/c9-6-3-1-2-5-4-10-8(11)7(5)6/h1-3H,4H2,(H,10,11) |
Molecular Formula | C8H6BrNO |
Molar Mass | 212.04 |
Density | 1.666±0.06 g/cm3(Predicted) |
Boling Point | 452.2±45.0 °C(Predicted) |
Flash Point | 227.266°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 13.36±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.625 |
Uses | 7-bromo-2, 3-dihydro-isoindole-1-one is a useful research chemical for organic synthesis and other chemical processes. |
Preparation | The condensation reaction of o-halomethyl or o-acyl benzoate with amines is a traditional method for synthesizing iso-indole ketone compounds. The selective reduction of phthalimide and various organic transformations of benzo [c] pyrrolidone derivatives are also used to synthesize iso-indole ketone derivatives. In this paper, the target compound 7-bromo-2, 3-dihydro-isoindole-1-one was prepared by ring-closing reaction with methyl 2-bromomethyl-3-chlorobenzoate and liquid ammonia as starting materials. The synthesis reaction formula is as follows: Experimental operation: Methyl 2-bromomethyl-3-chlorobenzoate and liquid ammonia are reacted in 20 mL methanol solution at 60°C under stirring to the end point (TLC detection). Chilled to room temperature, extracted with ethyl acetate, the organic phase was washed with saturated salt water for 3 times, anhydrous sodium sulfate was dried, concentrated and evaporated, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether, V/ V = 1/5) to obtain compound 7-bromo-2, 3-dihydro-indole-1-one. |