Molecular Formula | C34H50O12 |
Molar Mass | 650.75 |
Density | 1.1521 (rough estimate) |
Boling Point | 597.77°C (rough estimate) |
Solubility | DMSO: soluble |
Appearance | liquid or film |
Color | Colorless |
pKa | 10.57±0.70(Predicted) |
Storage Condition | -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
Sensitive | Heat and light sensitivity |
Refractive Index | 1.6390 (estimate) |
Physical and Chemical Properties | Bioactive Thapsigargin is an effective and non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2 + ATPase (SERCA). IC50 values for carbachol-induced [Ca2 +] I transients in the absence of KCl pre-stimulation are 0.353 nM and 0.448 nM respectively. Thapsigargin can induce apoptosis. Thapsigargin are extracted from plant Thapsia garganica. |
Use | Use carotene is a widely used inhibitor of endoplasmic reticulum Ca(2 )-ATPases in muscle cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium-releasing agent that blocks both angiostatin and endostatin-induced transient increases in intracellular Ca2 +. It induces apoptosis by disrupting intracellular free Ca2 + levels. |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42 - May cause sensitization by inhalation |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | RH0325700 |
HS Code | 29181990 |
Reference Show more | 1. [IF=2.629] Li Yi-Ming et al."Procyanidin B2 Alleviates Palmitic Acid-Induced Injury in HepG2 Cells via Endoplasmic Reticulum Stress Pathway."Evid-Based Compl Alt. 2021;2021:8920757 |