Name | N-Methyl-D-aspartic acid |
Synonyms | NMDA NMDA H-D-MEASP-OH N-ME-D-ASP-OH N-ME-D-ASP-OH HCL N-ME-D-ASPARTIC ACID N-Methyl-D-aspartic acid N-METHYL-D-ASPARTIC ACID N-METHYL-D-ASPARAGINIC ACID (R)-2-(Methylamino)succinic acid (2R)-2-(methylammonio)butanedioate N-METHYL-D-ASPARTIC ACID HYDROCHLORIDE |
CAS | 6384-92-5 |
EINECS | 227-012-0 |
InChI | InChI=1/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1 |
Molecular Formula | C5H9NO4 |
Molar Mass | 147.13 |
Density | 1.4285 (rough estimate) |
Melting Point | 187-192 °C |
Boling Point | 267.21°C (rough estimate) |
Specific Rotation(α) | -28 º (c=1, HCl 6N) |
Flash Point | 110°C |
Water Solubility | slightly soluble |
Solubility | DMSO 5 mg/mL Water 30 mg/mL Ethanol <1 mg/mL |
Vapor Presure | 0.0042mmHg at 25°C |
Appearance | White to white-like crystals |
Color | white |
Merck | 14,6662 |
BRN | 1724431 |
pKa | 2.21±0.23(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Sensitive | Hygroscopic |
Refractive Index | -15 ° (C=2, H2O) |
MDL | MFCD00004226 |
Physical and Chemical Properties | alpha:-28 o (c=1, HCl 6N) |
In vitro study | NMDA is an excitatory amino acid neurotransmitter that binds only to the NMDA receptor and does not affect other glutamate receptors (such as AMPA and Kainate). NMDA specifically binds to the NR2 subunit of the NMDA receptor and stimulates the opening of nonspecific cation channels, making Ca |
In vivo study | NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | CI9457000 |
FLUKA BRAND F CODES | 10 |
HS Code | 29225090 |
biological activity | NMDA (N-Methyl-D-aspartic acid) is a specific NMDA receptor agonist, mimics the activity of the neurotransmitter glutamate. Phase 4. |
Target | Value |
uses | release of extracellular toxic substances of amino acids; NMDA-type glutamate receptor prototype agonist with regulation of ion channels, |