Molecular Formula | C3HBr2N3O2 |
Molar Mass | 270.87 |
Density | 2.575 |
Melting Point | >270 °C |
Boling Point | 396℃ |
Flash Point | 193℃ |
Vapor Presure | 1.79E-06mmHg at 25°C |
pKa | 2.93±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.701 |
Overview | 2, 4-dibromo-5-nitro-1h-imidazole can be obtained from 4-nitroimidazole bromination. 2, 4-dibromo-5-nitro-1h-imidazole can be used for the preparation of 2-bromo-4-nitroimidazole. 2-bromo-4-nitroimidazole is an important intermediate in the synthesis of the bactericidal agent Delamanid, and 2-bromo-4-nitroimidazole (II) is also used in the synthesis of other nitroimidazoles under development. |
Application | 2, 4-dibromo-5-nitro-1h-imidazole is an intermediate in organic synthesis and a pharmaceutical intermediate, can be used in laboratory research and development process and chemical production process. |
preparation | in a 20L reactor equipped with a mechanical stirring and reflux condenser and exhaust gas receiving device, 4-nitroimidazole (1500g), distilled water (13L) and sodium bicarbonate (2458G) were added to the mixture, and bromine (1565ml) was added dropwise thereto under controlled temperature within 25 °c. After the dropwise addition was completed, the temperature was raised to 50-55 ° C. And the mixture was stirred until the reaction was complete. The heating was stopped, the temperature was lowered to 5 ° C., and the mixture was filtered. The resulting solid was washed twice with distilled water and dried under vacuum to give 3198G of 2, 5-dibromo-4-nitroimidazole as a yellow solid. |