Name | Quinine monohydrochloride dihydrate |
Synonyms | Quinine Monohy Quinine HCl Dihydrate Quinine monohydrochloride dihydrate QUININEHYDROCHLORIDE,DIHYDRATE,CRYSTAL (9R)-6'-methoxycinchonan-1'-ium-9-ol chloride dihydrate (8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate (4beta,8alpha,9R)-6'-methoxycinchonan-9-ol hydrochloride dihydrate Cinchonan-9-ol, 6-methoxy-, monohydrochloride, dihydrate, (8.alpha.,9R)- (R)(6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol hydrochloride (R)(6-methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol monohydrochloride dihydrate |
CAS | 6119-47-7 |
EINECS | 612-097-2 |
InChI | InChI=1/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13?,14?,19?,20-;;;/m1.../s1 |
InChIKey | MPQKYZPYCSTMEI-HPVDNOPASA-N |
Molecular Formula | C20H27ClN2O3 |
Molar Mass | 378.9 |
Melting Point | 115-116°C (dec.)(lit.) |
Boling Point | 495.9°C at 760 mmHg |
Specific Rotation(α) | [α]D20 -245~-255° (c=2, dil. HCl) (After Drying) |
Flash Point | 122 °C |
Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
Solubility | H2O: soluble0.25/5g/mL, clear, colorless |
Vapor Presure | 1.19E-10mmHg at 25°C |
Appearance | Crystalline Powder or Silky Needles |
Color | White to off-white |
Merck | 14,8061 |
BRN | 6112655 |
PH | 6.0 (10g/l, H2O, 20℃) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Sensitive | Light Sensitive |
Refractive Index | -250 ° (C=2, EtOH) |
MDL | MFCD00151248 |
Use | K channel blocker. |
In vitro study | Quinine blocked the Cx36 and Cx50 junction currents in a reversible and concentration-dependent manner, with half-maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces a slow transition between the open and fully closed states, which reduces the open probability of the channel. Quinine prevents certain types of gap junction channels, including those between neurons, from forming through CX36. Quinine, a K-channel blocker, prevents the formation of tumor necrosis factor (TNF) and subsequent liver DNA fragmentation and liver enzyme leakage. Quinine caused a Fos-like immune response (FLI) to concentrate in the medial third nucleus; Acid caused a more widespread FLI concentration more laterally. Quinine had a relatively weak effect on doxorubicin accumulation but completely restored doxorubicin sensitivity in resistant cells. Quinine also modified intracellular accumulation of doxorubicin, suggesting a modified intracellular drug distribution. Quinine predominantly blocks the voltage dependence in the whole-cell potassium current (IK). Quinine has also been used to dependently reduce sodium current (INa) while leaving calcium current (ICA) relatively unaffected. |
Risk Codes | R22 - Harmful if swallowed R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | VA7700000 |
FLUKA BRAND F CODES | 8 |
HS Code | 29392000 |
Hazard Note | Irritant |
Toxicity | LD50 orally in Rabbit: 620 mg/kg |