6035-45-6
Calcium Folinatc
CAS: 6035-45-6
Molecular Formula: C20H21CaN7O7
6035-45-6 - Names and Identifiers
6035-45-6 - Physico-chemical Properties
| Molecular Formula | C20H21CaN7O7 |
| Molar Mass | 511.5 |
| Melting Point | 240-250°C |
| Specific Rotation(α) | D21 +14.9° (c = 1 in water) |
| Water Solubility | It is soluble in water, but almost insoluble in ethanol or ether; it is soluble in 0.1mol/l sodium hydroxide solution |
| Appearance | powder |
| Color | Yellow-white to yellow |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| In vitro study | Leucovorin increases the reduced levels of folate in tissues, thereby promoting the inhibition of thymidylate synthase in both mouse colon tumors. Leucovorin,Gemcitabine, Oxaliplatin and 5-fluorouracil are a powerful anti-tumor and immunomodulatory therapy that can make tumor cells suitable means to induce antigen-specific CTL responses. In 11 human colon cancer cell lines, Leucovorin(20 mM) increased cytotoxicity. In CCRF-CEM cells, Leucovorin potentiated trimethyl/Fluorouracil toxicity but not methotrexate/Fluorouracil. In tumor and normal tissues, Leucovorin(LV) is a reduced folate cofactor that competes with RTX for transport and polyglutamation, and thus can serve as a potential rescue agent. Leucovorin reverses growth inhibition and potentiates the cytotoxic effects of RTX. |
| In vivo study | In mice, the administration of Leucovorin(200 mg/kg) after severe weight loss and diarrhea (twice daily for 5-7 days) prevented further weight loss and caused early recovery. Compared with the control group, Leucovorin(100 or 200 mg/kg; Once every two days, 4-6 days) reduced the concentration of RTX in the liver by 2-4 times. The combination of Leucovorin/5-FU and gastricmmune (200 mg/mL) increased the growth of DHDK12 tumors in vivo. |
6035-45-6 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29362900 |
6035-45-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.955 ml | 9.775 ml | 19.55 ml |
| 5 mM | 0.391 ml | 1.955 ml | 3.91 ml |
| 10 mM | 0.196 ml | 0.978 ml | 1.955 ml |
| 5 mM | 0.039 ml | 0.196 ml | 0.391 ml |
Last Update：2024-01-02 23:10:35
6035-45-6 - Reference Information
| Update Date: | 2022/11/12 10:05:38 |
| biological activity | Leucovorin (Folinic acid) is a Folinic acid that is used to improve folate decline. |
| Target | Value |
Last Update：2024-04-09 21:21:28
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View History
6035-45-6
1379336-26-1
[N-(29H,31H-phthalocyaninylmethyl)piperidine-1-acetamidato(2-)-N29,N30,N31,N32]copper
7(4H)-Benzothiazolone, 2-amino-6-bromo-5,6-dihydro-
6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile
N-(4-bromophenyl)-4-tert-butylbenzamide
1258984-36-9
Methyl 2-(3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetate
5-ethyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide
(2S,4R)-Methyl 1-benzoyl-4-(tosyloxy)-pyrrolidine-2-carboxylate
1379336-26-1
[N-(29H,31H-phthalocyaninylmethyl)piperidine-1-acetamidato(2-)-N29,N30,N31,N32]copper
7(4H)-Benzothiazolone, 2-amino-6-bromo-5,6-dihydro-
6-amino-4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-ethoxyquinoline-3-carbonitrile
N-(4-bromophenyl)-4-tert-butylbenzamide
1258984-36-9
Methyl 2-(3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetate
5-ethyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide
(2S,4R)-Methyl 1-benzoyl-4-(tosyloxy)-pyrrolidine-2-carboxylate